Publications
Recent publications from members of our department are shown below. View a full list of publications on Pubmed
Chemogenetic model of acute temporal lobe-like seizures in the area tempestas
The piriform cortex was identified as a crucial ictogenic trigger zone in the 1980s. Surgical outcome studies in humans likewise suggest that this region contributes to seizure generation. Within the …
August 7th, 2026
Aggregation of α-synuclein protein is a characteristic of Parkinson’s disease pathology that relates to the degeneration of vulnerable dopaminergic neurons and motor symptoms of the disease. However,…
July 29th, 2026
Irisin upregulation as a contributory mechanism for the therapeutic benefits of SGLT-2 inhibitors
Different pharmacological and non-pharmacological interventions have been suggested for the management of blood glucose, among which are sodium-glucose cotransporter-2 (SGLT-2) inhibitors and exercise…
July 29th, 2026
Acute stress can facilitate learning about stimuli that predict rewarding outcomes, yet whether stress similarly potentiates acquisition of reward-directed actions remains less well understood. Reward…
July 29th, 2026
Across mammals, brain regions can duplicate, expand, and diversify, requiring long-range connectivity to accommodate species-specific specializations while preserving globally ordered wiring. This cha…
July 17th, 2026
INTRODUCTION: Tricyclic drugs such as chlorpromazine (CPZ), amitriptyline (AmiT), and imipramine (ImiP) have demonstrated antitumorigenic potential, yet their relative potency and selectivity for diff…
July 17th, 2026
CONCLUSIONS: Regional brain AT(1)R levels were not significantly dysregulated in Tg-SwDI mice compared to wild-type mice. Additionally, drug treatment with sub-depressor doses of the AT(1)R antagonist…
July 13th, 2026
CONCLUSIONS: Menopausal hormone therapy in young menopausal women has not been shown in randomized controlled trials to have beneficial effects on cardiovascular disease, cancer, depression, or cognit…
July 1st, 2026
Microglia are dynamic cells that respond both transcriptionally and morphologically to acute brain injury as well as to chronic neurodegenerative conditions. Upon activation, they become less ramified…
June 25th, 2026
Emergence of Task-Related Motor Cortical Dysfunction in Mice with Progressive Parkinsonism
There are substantial functional changes in the primary motor cortex (M1) in Parkinson’s disease (PD). However, the temporal relationship between midbrain dopaminergic (DA) neurodegeneration, M1 circu…
June 12th, 2026
Macroscopic Pulmonary Fat Embolism Secondary to Intraosseous Line Placement: A Case Report
CONCLUSIONS: Although intraosseous access is often considered a safe procedure, this case highlights the need for awareness of this rare but serious and potentially lethal complication. Treatment of p…
June 11th, 2026
Sex-specific effects of exercise on motor coordination and extended basal ganglia physiology
Exercise broadly affects the basal ganglia, brain structures involved in motor coordination. Exercise-induced changes in these regions can improve pathological conditions such as Parkinson’s disease a…
May 4th, 2026
Epilepsy is increasingly recognized as a disorder of brain networks rather than a solely focal disease. Beyond the seizure focus, connected brain networks can exert inhibitory control over seizure ini…
April 20th, 2026
Ether-a-go-go 1 (EAG1) potassium channels are overexpressed in the majority of cancers, and inhibition of their activity decreases cancer growth and migration. Here, we show that amitriptyline (AmiT),…
April 16th, 2026
OBJECTIVE: Current pharmacotherapy for temporal lobe epilepsy (TLE) is limited to symptomatic treatment and leaves approximately one third of patients with inadequate seizure control. Discovering dise…
April 13th, 2026
Granuloma formation often complicates the implantation of foreign materials, causing tissue inflammation and adverse effects. This study assessed the efficacy of polyethersulfone (PES) films in reduci…
April 7th, 2026
APOE4 is a risk factor for several disease states associated with cognitive impairment, including Alzheimer’s disease and cancer-chemotherapy induced cognitive impairment. Using mouse knock-in models …
March 26th, 2026
Temporal and Cell-Specific Regulation of Synaptic Homeostasis by the Chromatin Remodeler Chd1
Disruptions in chromatin remodelers and synaptic proteins represent major genetic risk factors for autism spectrum disorder (ASD), yet how these distinct gene classes converge to impair circuit functi…
March 15th, 2026
Chlorpromazine inhibits EAG1 channels by altering the interdomain coupling
EAG1 depolarization-activated potassium selective channels are important targets for treatment of cancer and neurological disorders. EAG1 channels are formed by a tetrameric subunit assembly with each…
March 7th, 2026
INAFM2, the human homolog of the Drosophila inaF, is a predicted membrane protein with no known function in vertebrates. Through an in vivo genome-wide transcriptional activation screen, we uncovered …
February 6th, 2026