Publications

Recent publications from members of our department are shown below. View a full list of publications on Pubmed

Deep Hypothermic Circulatory Arrest Duration and Neurologic Outcomes in Pulmonary Thromboendarterectomy

CONCLUSIONS: Extended DHCA was not independently associated with neurological events after PTE but was independently associated with MACE. Balancing total circulatory arrest duration with complete bil…

October 1st, 2026

Antioxidant Properties of a <em>Rhodiola rosea</em> Constituent, Rosavin

Rhodiola rosea is a traditional medicinal plant with reported effects in supporting the body’s response to physical, environmental, and emotional stressors. The present study investigated the antioxid…

September 26th, 2026

EAG1 channel is a central regulator of tumor growth and metastasis in A549 non-small cell lung cancer cells

The voltage-gated potassium channel EAG1 is aberrantly expressed in many cancers, yet its mechanistic contributions to tumor growth and metastasis in non-small cell lung cancer (NSCLC) remains poorly …

September 22nd, 2026

Structural and functional significance of arginine at position 2 of angiotensin II: Implications for oxidant-mediated amino acid residue conversions

Angiotensin II (Ang II) is a peptide hormone that regulates vascular tone and blood pressure. Angiotensin-converting enzyme generates Ang II from angiotensin I, whereas angiotensin-converting enzyme 2…

September 17th, 2026

Bridging the gut and mind: a narrative review of depression in Crohn's disease and emerging gut-brain axis therapies

Depression is a highly prevalent and clinically significant comorbidity in Crohn’s disease (CD), a form of inflammatory bowel disease (IBD), and is associated with increased disease activity, hospital…

September 8th, 2026

Chemogenetic model of acute temporal lobe-like seizures in the area tempestas

The piriform cortex was identified as a crucial ictogenic trigger zone in the 1980s. Surgical outcome studies in humans likewise suggest that this region contributes to seizure generation. Within the …

August 7th, 2026

α-Synuclein pathology differentially alters T-type calcium currents in vulnerable and resilient substantia nigra dopaminergic subpopulations

Aggregation of α-synuclein protein is a characteristic of Parkinson’s disease pathology that relates to the degeneration of vulnerable dopaminergic neurons and motor symptoms of the disease. However,…

July 29th, 2026

Irisin upregulation as a contributory mechanism for the therapeutic benefits of SGLT-2 inhibitors

Different pharmacological and non-pharmacological interventions have been suggested for the management of blood glucose, among which are sodium-glucose cotransporter-2 (SGLT-2) inhibitors and exercise…

July 29th, 2026

Acute stress induces circuit-specific alterations in mesolimbic and nigrostriatal inhibitory transmission and potentiates operant learning

Acute stress can facilitate learning about stimuli that predict rewarding outcomes, yet whether stress similarly potentiates acquisition of reward-directed actions remains less well understood. Reward…

July 29th, 2026

Conserved and specialized features of thalamocortical wiring revealed by single-cell projection mapping in mouse and marmoset

Across mammals, brain regions can duplicate, expand, and diversify, requiring long-range connectivity to accommodate species-specific specializations while preserving globally ordered wiring. This cha…

July 17th, 2026

Repurposing tricyclic drugs as cancer therapeutics: comparative analysis of antitumorigenic effects of chlorpromazine, amitriptyline and imipramine

INTRODUCTION: Tricyclic drugs such as chlorpromazine (CPZ), amitriptyline (AmiT), and imipramine (ImiP) have demonstrated antitumorigenic potential, yet their relative potency and selectivity for diff…

July 17th, 2026

Evaluating AT<sub>1</sub>R expression and the effects of renin-angiotensin system inhibition in a mouse model of cerebral amyloid angiopathy

CONCLUSIONS: Regional brain AT(1)R levels were not significantly dysregulated in Tg-SwDI mice compared to wild-type mice. Additionally, drug treatment with sub-depressor doses of the AT(1)R antagonist…

July 13th, 2026

The effects of menopausal hormone therapy on cardiovascular disease, cancer, cognition and depression in younger women: A systematic review

CONCLUSIONS: Menopausal hormone therapy in young menopausal women has not been shown in randomized controlled trials to have beneficial effects on cardiovascular disease, cancer, depression, or cognit…

July 1st, 2026

Plasma Membrane Remodeling During Microglial Activation: A Hypothesis Linking Microglial Shape and Lipid Droplet Formation

Microglia are dynamic cells that respond both transcriptionally and morphologically to acute brain injury as well as to chronic neurodegenerative conditions. Upon activation, they become less ramified…

June 25th, 2026

Acute stress induces circuit-specific alterations in mesolimbic and nigrostriatal inhibitory transmission and potentiates operant learning

Acute stress can facilitate learning about stimuli that predict rewarding outcomes, yet whether stress similarly potentiates acquisition of reward-directed actions remains less well understood. Reward…

June 22nd, 2026

Emergence of Task-Related Motor Cortical Dysfunction in Mice with Progressive Parkinsonism

There are substantial functional changes in the primary motor cortex (M1) in Parkinson’s disease (PD). However, the temporal relationship between midbrain dopaminergic (DA) neurodegeneration, M1 circu…

June 12th, 2026

Macroscopic Pulmonary Fat Embolism Secondary to Intraosseous Line Placement: A Case Report

CONCLUSIONS: Although intraosseous access is often considered a safe procedure, this case highlights the need for awareness of this rare but serious and potentially lethal complication. Treatment of p…

June 11th, 2026

Sex-specific effects of exercise on motor coordination and extended basal ganglia physiology

Exercise broadly affects the basal ganglia, brain structures involved in motor coordination. Exercise-induced changes in these regions can improve pathological conditions such as Parkinson’s disease a…

May 4th, 2026

Antiseizure Networks

Epilepsy is increasingly recognized as a disorder of brain networks rather than a solely focal disease. Beyond the seizure focus, connected brain networks can exert inhibitory control over seizure ini…

April 20th, 2026