Publications
Recent publications from members of our department are shown below. View a full list of publications on Pubmed
Motor cortical neuronal hyperexcitability associated with α-synuclein aggregation
ΑBSTRACT: In Parkinson’s disease (PD), Lewy pathology deposits in the cerebral cortex, but how the pathology disrupts cortical circuit integrity and function remains poorly understood. To begin to ad…
January 14th, 2025
Sub-second characterization of locomotor activities of mouse models of Parkinsonism
The degeneration of midbrain dopamine (DA) neurons disrupts the neural control of natural behavior, such as walking, posture, and gait in Parkinson’s disease. While some aspects of motor symptoms can …
January 7th, 2025
Aging affects virtually all organs of the body, but perhaps it has the most profound effects on the brain and its neurotransmitter systems, which influence a wide range of crucial functions, such as a…
December 10th, 2024
Piriform cortex is an ictogenic trigger zone in the primate brain
OBJECTIVE: Area tempestas, a functionally defined region in the anterior piriform cortex, was identified as a crucial ictogenic trigger zone in the rat brain in the 1980s. However, whether the primate…
December 5th, 2024
Progressive noradrenergic degeneration and motor cortical dysfunction in Parkinson's disease
The locus coeruleus norepinephrine (LC-NE) system plays an important role in regulating brain function, and its neuronal loss has been well-documented in Parkinson’s disease (PD). The LC-NE neurodegen…
November 26th, 2024
VICR: A novel software for unbiased video and image analysis in scientific research
In scientific research, objectivity and unbiased data analysis is crucial for the validity and reproducibility of outcomes. This is particularly important for studies involving video or image categori…
October 24th, 2024
Assessment of the therapeutic potential of salubrinal for ME/CFS and long-COVID
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a chronic debilitating condition with no cure that shares commonality with long-COVID. This review examines current understanding of long…
October 22nd, 2024
α-Synuclein aggregation decreases cortico-amygdala connectivity and impairs social behavior in mice
Abnormal accumulation of insoluble α-synuclein (α-Syn) inclusions in neurons, neurites, and glial cells is the defining neuropathology of synucleinopathies, including Parkinson’s disease (PD), demen…
October 15th, 2024
Mass spectrometry identifies tau C-terminal phosphorylation cluster during neuronal hyperexcitation
Tau is a microtubule-associated protein implicated in Alzheimer’s disease (AD) and other neurodegenerative disorders termed tauopathies. Pathological, aggregated forms of tau form neurofibrillary tang…
September 23rd, 2024