Publications
Recent publications from members of our department are shown below. View a full list of publications on Pubmed
Background: Immunotherapy has revolutionized oncology care, but clinical response to immune checkpoint inhibitors (ICIs) remains unpredictable, and treatment carries substantial risks and costs. The E…
September 13th, 2025
A Journey between Neurons and Astrocytes: A Tribute to Giorgio Carmignoto
The intimate relation between astrocytes and blood vessels was proposed by Camillo Golgi in 1870. Santiago Ramon y Cajal subsequently introduced the idea of astrocytes as regulators of functional hype…
September 4th, 2025
Comprehensive Evaluation of Cleavable Bioorthogonal Probes for Site-Specific O-GlcNAc Proteomics
O-linked β-N-acetylglucosamine (O-GlcNAc) modification (i.e., O-GlcNAcylation) on proteins is an essential modification in physiology and pathology. Although O-GlcNAcylation is functionally critical,…
August 30th, 2025
Cocaine and Morphine Converge to Disrupt Chloride Homeostasis in Ventral Tegmental Area GABA Neurons
Identifying shared neural mechanisms influenced by diverse classes of drugs of abuse is essential for understanding addiction and for developing broad-spectrum treatments for substance use disorders. …
August 8th, 2025
Enhanced beta power emerges from simulated parkinsonian primary motor cortex
Primary motor cortex (M1) layer 5B pyramidal tract (PT5B) neurons develop intrinsic pathology in rodent and primate Parkinson’s disease (PD) models. We used computer simulation to predict how decrease…
August 5th, 2025
Subsecond Analysis of Locomotor Activity in Parkinsonian Mice
The degeneration of midbrain dopamine (DA) neurons disrupts the neural control of natural behavior, such as walking, posture, and gait in Parkinson’s disease. While some aspects of motor symptoms can …
July 28th, 2025
EpiSwitch PSE Blood Test Reduces Unnecessary Prostate Biopsies: A Real-World Clinical Utility Study
Background/Objectives: Prostate cancer (PCa) remains a major contributor to cancer-related morbidity and mortality worldwide. Current diagnostic strategies, largely based on PSA screening, lack specif…
July 12th, 2025
Triglyceride metabolism controls inflammation and microglial phenotypes associated with APOE4
Changes to cellular lipids accompany shifts in microglial cell state, but the functional significance of these metabolic changes remains poorly understood. In human induced pluripotent stem cell-deriv…
July 11th, 2025
Rigorous and transparent procedures in preclinical epilepsy research studies are important to permit assessing the reproducibility of their findings and derisk their translation into the clinic. The G…
June 26th, 2025
CONCLUSIONS: CAA did not significantly dysregulate AT(1)R levels in the brains of Tg-SwDI mice compared to wild-type mice. Drug treatment caused no significant brain AT(1)R alterations. Further studie…
June 6th, 2025
The incidence of chronic pain in the general population is highly correlated to anxiety disorders, which promote negative effects on the quality of life. Stretch injury is the primary cause of nerve d…
June 4th, 2025
Arteries are finely tuned thermosensors regulating myogenic tone and blood flow
In response to changing blood pressure, arteries adjust their caliber to control blood flow. This vital autoregulatory property, termed vascular myogenic tone, stabilizes downstream capillary pressure…
May 20th, 2025
Sharp wave ripple (SWR) events, present in diverse species, spontaneously occur in the hippocampus during quiescent restfulness and slow-wave sleep. SWRs comprise a negative deflection, the sharp wave…
May 2nd, 2025
Fractal dimension (FD) is a widely recognized metric in mathematics and physics for quantifying the complexity of intricate objects and processes. In this study, we propose novel algorithms to estimat…
April 15th, 2025
Optogenetic stimulation of the dorsal striatum bidirectionally controls seizures
Despite a century of development of antiseizure medications, up to a third of people with epilepsy do not achieve seizure freedom with drug therapy. Deep brain stimulation is of growing use, but just …
March 31st, 2025
Rising Trends in Prostate Cancer Among Asian Men: Global Concerns and Diagnostic Solutions
Asia comprises 60% of the global male population, yet Asian men’s health issues, such as prostate cancer, remain sparse in the literature. Clinical researchers have often overlooked prostate cancer in…
March 28th, 2025
NAD+ prevents chronic kidney disease by activating renal tubular metabolism
Chronic kidney disease (CKD) is associated with renal metabolic disturbances, including impaired fatty acid oxidation (FAO). Nicotinamide adenine dinucleotide (NAD+) is a small molecule that participa…
March 10th, 2025
Phosphorylation of NLGN4X Regulates Spinogenesis and Synaptic Function
Neuroligins (NLGNs) are a family of postsynaptic adhesion molecules that bind to their presynaptic partners, neurexins, facilitating the formation and maintenance of synapses. In humans, there are fiv…
March 3rd, 2025
Muscarinic Receptor Activation Preferentially Inhibits Rebound in Vulnerable Dopaminergic Neurons
Dopaminergic subpopulations of the substantia nigra pars compacta (SNc) differentially degenerate in Parkinson’s disease and are characterized by unique electrophysiological properties. The vulnerable…
February 25th, 2025
The melanocortin receptors are a class of centrally and peripherally expressed G protein-coupled receptors, of which the MC3R and MC4R subtypes are implicated in the regulation of appetite and energy …
January 20th, 2025