Publications
Recent publications from members of our department are shown below. View a full list of publications on Pubmed
CONCLUSIONS: Female Syrian hamsters exhibit heightened vulnerability to Ang II-induced hypertension and renal damage compared to males, marked by exaggerated blood pressure elevation, enhanced renal i…
November 4th, 2025
OBJECTIVE: For over four decades, the substantia nigra pars reticulata (SNr) has been recognized as a critical structure in the modulation of seizure activity. Pharmacological and optogenetic inhibiti…
November 3rd, 2025
CONCLUSIONS: β-Nic slows Nic clearance in rats and enhances and prolongs the discriminative stimulus effects of Nic, suggesting it may contribute to the abuse liability of ENDS.…
November 2nd, 2025
Serotonin transporter: a potential new immune checkpoint for cytotoxic T cells
No abstract…
October 29th, 2025
Oxidized angiotensin II peptides as mediators of cell signaling?
Both reactive oxygen species (ROS) and angiotensin II (Ang II) play important roles in the pathogenesis of various diseases. Since Ang II was found to activates NADPH oxidase to produce ROS, many labo…
October 23rd, 2025
Cerebral amyloid angiopathy: a narrative review
Cerebral amyloid angiopathy (CAA) is a cerebrovascular disorder characterized by the accumulation of amyloid-beta (Aβ) in the walls of cerebral vessels. It is commonly associated with cognitive decli…
October 2nd, 2025
In people with HIV (PWH), T cell immune activation and endothelial inflammation are contributors of the increased cardiovascular risk, however the mechanisms remain poorly understood. PAR1 connects th…
October 1st, 2025
Background: Immunotherapy has revolutionized oncology care, but clinical response to immune checkpoint inhibitors (ICIs) remains unpredictable, and treatment carries substantial risks and costs. The E…
September 13th, 2025
A Journey between Neurons and Astrocytes: A Tribute to Giorgio Carmignoto
The intimate relation between astrocytes and blood vessels was proposed by Camillo Golgi in 1870. Santiago Ramon y Cajal subsequently introduced the idea of astrocytes as regulators of functional hype…
September 4th, 2025
Comprehensive Evaluation of Cleavable Bioorthogonal Probes for Site-Specific O-GlcNAc Proteomics
O-linked β-N-acetylglucosamine (O-GlcNAc) modification (i.e., O-GlcNAcylation) on proteins is an essential modification in physiology and pathology. Although O-GlcNAcylation is functionally critical,…
August 30th, 2025
Cocaine and Morphine Converge to Disrupt Chloride Homeostasis in Ventral Tegmental Area GABA Neurons
Identifying shared neural mechanisms influenced by diverse classes of drugs of abuse is essential for understanding addiction and for developing broad-spectrum treatments for substance use disorders. …
August 8th, 2025
Enhanced beta power emerges from simulated parkinsonian primary motor cortex
Primary motor cortex (M1) layer 5B pyramidal tract (PT5B) neurons develop intrinsic pathology in rodent and primate Parkinson’s disease (PD) models. We used computer simulation to predict how decrease…
August 5th, 2025
Subsecond Analysis of Locomotor Activity in Parkinsonian Mice
The degeneration of midbrain dopamine (DA) neurons disrupts the neural control of natural behavior, such as walking, posture, and gait in Parkinson’s disease. While some aspects of motor symptoms can …
July 28th, 2025
EpiSwitch PSE Blood Test Reduces Unnecessary Prostate Biopsies: A Real-World Clinical Utility Study
Background/Objectives: Prostate cancer (PCa) remains a major contributor to cancer-related morbidity and mortality worldwide. Current diagnostic strategies, largely based on PSA screening, lack specif…
July 12th, 2025
Triglyceride metabolism controls inflammation and microglial phenotypes associated with APOE4
Changes to cellular lipids accompany shifts in microglial cell state, but the functional significance of these metabolic changes remains poorly understood. In human induced pluripotent stem cell-deriv…
July 11th, 2025
Rigorous and transparent procedures in preclinical epilepsy research studies are important to permit assessing the reproducibility of their findings and derisk their translation into the clinic. The G…
June 26th, 2025
CONCLUSIONS: CAA did not significantly dysregulate AT(1)R levels in the brains of Tg-SwDI mice compared to wild-type mice. Drug treatment caused no significant brain AT(1)R alterations. Further studie…
June 6th, 2025
The incidence of chronic pain in the general population is highly correlated to anxiety disorders, which promote negative effects on the quality of life. Stretch injury is the primary cause of nerve d…
June 4th, 2025
Arteries are finely tuned thermosensors regulating myogenic tone and blood flow
In response to changing blood pressure, arteries adjust their caliber to control blood flow. This vital autoregulatory property, termed vascular myogenic tone, stabilizes downstream capillary pressure…
May 20th, 2025
Sharp wave ripple (SWR) events, present in diverse species, spontaneously occur in the hippocampus during quiescent restfulness and slow-wave sleep. SWRs comprise a negative deflection, the sharp wave…
May 2nd, 2025