Dr. Kyle Kihn is a postdoctoral fellow at Georgetown University Medical Center, specializing in pharmacology and physiology. His educational background includes a B.A. in Molecular Biology and Biochemistry from Goucher College and a Ph.D. in Pharmaceutical Sciences from the University of Maryland, Baltimore. Dr. Kihn’s research interests lie at the intersection of experimental biophysics and computational modeling, focusing on the use of molecular dynamics simulations and machine learning to advance therapeutic discovery.
During his Ph.D., Dr. Kihn combined hydrogen deuterium exchange mass spectrometry (HDX-MS) with molecular dynamics simulations to study protein dynamics, enhancing the understanding of protein-ligand interactions and protein flexibility. Currently, his work focuses on applying artificial intelligence to drug discovery, particularly in developing inhibitors for the KCNH1 potassium channel, a target in metastatic clear-cell renal cell carcinoma. By integrating computational techniques with experimental data, Dr. Kihn aims to create highly specific and effective cancer therapies, contributing to the broader field of precision medicine and advancing the understanding of protein dynamics at an atomic level.
Academic Appointment(s)
- Secondary
- Post Doctoral Fellow, Brelidze Lab