Publications

Because research is such an important aspect of our programs, we include links to recent faculty publications. Click any title to read the abstract.

• 2019
• 2018
• 2017
• 2016

2019

• GABAB Receptor Signaling in the Dorsal Motor Nucleus of the Vagus Stimulates Gastric Motility via a Cholinergic Pathway Front Neurosci. 13:967, 2019
• The Angiotensin Type 1 Receptor Antagonist Losartan Prevents Ovariectomy-Induced Cognitive Dysfunction and Anxiety-Like Behavior in Long Evans Rats. Cell Mol Neurobiol. Oct 21, 2019
• Reversal of Cognitive Impairment in gp120 Transgenic Mice by the Removal of the p75 Neurotrophin Receptor. Front Cell Neurosci. 13:398, 2019
• Histone deacetylase 6 inhibition rescues axonal transport impairments and prevents the neurotoxicity of HIV-1 envelope protein gp120. Cell Death Dis. 10(9):674, 2019
• Antioxidant Regulation of Cell Reprogramming. Antioxidants (Basel). 8(8). pii: E323, 2019
• Inhibition of Polo-like kinase 2 ameliorates pathogenesis in Alzheimer’s disease model mice. PLoS One. 14(7):e0219691, 2019
• Measuring Sharp Waves and Oscillatory Population Activity With the Genetically Encoded Calcium Indicator GCaMP6f. Front Cell Neurosci. 13:274, 2019
• Identification of undecylenic acid as EAG channel inhibitor using surface plasmon resonance-based screen of KCNH channels. BMC Pharmacol Toxicol. 20(1):42, 2019
• Transmission Electron Microscopy Study of Mitochondria in Aging Brain Synapses  Antioxidants (Basel). 8(6), 2019
• A Role for Matrix Metalloproteases in Antidepressant Efficacy  Front Mol Neurosci. 12:117, 2019
• Protein Redox State Monitoring Studies of Thiol Reactivity  Antioxidants (Basel)8(5), 2019
• Serum Amyloid A Protein as a Potential Biomarker for Severity and Acute Outcome in Traumatic Brain Injury  Biomed Res Int. :5967816, 2019
• Metabolomics Studies to Assess Biological Functions of Vitamin E Nicotinate  Antioxidants (Basel) 8(5), 2019
• Electroconvulsive Shock Enhances Responsive Motility and Purinergic Currents in Microglia in the Mouse Hippocampus  eNeuro. Apr 23;6(2), 2019
• Juglone in Oxidative Stress and Cell Signaling  Antioxidants (Basel). Apr 5;8(4), 2019
• Pharmacokinetics and pharmacodynamics of a single dose Nilotinib in individuals with Parkinson’s disease  Pharmacol Res Perspect. Mar 12;7(2), 2019
• HIV-associated neurodegeneration: exploitation of the neuronal cytoskeleton  J Neurovirol. Mar 8. 2019
  Oxidant-Mediated Protein Amino Acid Conversion  Antioxidants (Basel). Feb 25;8(2), 2019
• The Pressor Response to Concurrent Stimulation of the Mesencephalic Locomotor Region and Peripheral Sensory Afferents Is Attenuated in Normotensive but Not Hypertensive Rats  Front Physiol. Feb 13;10:95, 2019
• N- and C-terminal interactions in KCNH channels: The spotlight on the intrinsic ligand.  J Gen Physiol. Feb 19, 2019
• Oral sazetidine-A, a selective α4β2* nicotinic receptor desensitizing agent, reduces nicotine self-administration in rats  Pharmacol Biochem Behav. Feb 19, 2019
• Preclinical safety and efficacy of cannabidivarin for early life seizures. Neuropharmacology. Jan 8, 2019
• MALAT1 Up-Regulator Polydatin Protects Brain Microvascular Integrity and Ameliorates Stroke Through C/EBPβ/MALAT1/CREB/PGC-1α/PPARγ Pathway. Cell Mol Neurobiol. Jan 3, 2019
• Should medical device representatives assist surgeons? J Eval Clin Pract. Jan 9, 2019

2018

• α4β2 Nicotinic receptor desensitizing compounds can decrease self-administration of cocaine and methamphetamine in rats. Eur J Pharmacol. 845:1-7, 2018
• Colocalization of Tectal Inputs With Amygdala-Projecting Neurons in the Macaque Pulvinar. Front Neural Circuits. 12:91, 2018
• MMP-1 overexpression selectively alters inhibition in D1 spiny projection neurons in the mouse nucleus accumbens core Sci Rep. 8:16230, 2018
• Effects of Bcl-2/Bcl-xL Inhibitors on Pulmonary Artery Smooth Muscle Cells Antioxidants (Basel) Oct 26, 2018
• Impact of strain, sex, and estrous cycle on gamma butyrolactone-evoked absence seizures in rats Epilepsy Res 147:62-70, 2018
• Ligand-mediated dephosphorylation signaling for MAP kinase Cell Signal. 52:147-154, 2018
• Neuroprotective Action of the CB1/2 Receptor Agonist, WIN 55,212-2, against DMSO but Not Phenobarbital-Induced Neurotoxicity in Immature Rats Neurotox Res. Aug 24, 2018
• Telmisartan Protects a Microglia Cell Line from LPS Injury Beyond AT1 Receptor Blockade or PPARγ Activation Mol Neurobiol. Aug 13, 2018
• Redox Biology of Right-Sided Heart Failure Antioxidants (Basel). Aug 8, 2018
• Isoform-specific cleavage of neuroligin-3 reduces synapse strength Mol Psychiatry. Sep 21 2018
• The Role of Metabotropic Glutamate Receptor 1 Dependent Signaling in Glioma Viability. J Pharmacol Exp Ther. 367:59-70, 2018 
• Genetically Epilepsy-Prone Rats Display Anxiety-Like Behaviors and Neuropsychiatric Comorbidities of Epilepsy. Front Neurol. 9:476, 2018
• Differential electrophysiological properties of D1 and D2 spiny projection neurons in the mouse nucleus accumbens core. Physiol Rep. Jul;6(13):e13784, 2018
• Inhibition of the substantia nigra pars reticulata produces divergent effects on sensorimotor gating in rats and monkeys. Sci Rep. 8:9369, 2018
• Proceedings of the Epilepsy Foundation’s 2017 Cannabinoids in Epilepsy Therapy Workshop. Epilepsy Behav. 85:237-242, 2018
• Divergent effects of levetiracetam and tiagabine against spontaneous seizures in adult rats following neonatal hypoxia. Epilepsy Res. 140:1-7, 2018
• Mediodorsal thalamus is required for discrete phases of goal-directed behavior in macaques Elife. 2018 May 31;7. pii: e37325. doi: 10.7554/eLife.37325
• Effects of systemic cholinergic antagonism on reinforcer devaluation in macaques. Neurosci Lett. 678:62-67, 2018
• Pacing Hippocampal Sharp-Wave Ripples With Weak Electric Stimulation. Front Neurosci. 12:164, 2018
• Subdiaphragmatic Vagotomy With Pyloroplasty Ameliorates the Obesity Caused by Genetic Deletion of the Melanocortin 4 Receptor in the Mouse Front Neurosci. 12:104, 2018
• Proteolytic Remodeling of Perineuronal Nets: Effects on Synaptic Plasticity and Neuronal Population Dynamics Neural Plast. 2018:5735789, 2018
• Effects of nicotine-containing and “nicotine-free” e-cigarette refill liquids on intracranial self-stimulation in rats Drug Alcohol Depend. 185:1-9, 2018
• What goes up must come down: homeostatic synaptic plasticity strategies in neurological disease Future Neurol. 13:13-21, 2018
• A pilot study of the role of the claustrum in attention and seizures in rats Epilepsy Res. 140:97-104, 2018
• Neonatal phenobarbital exposure disrupts GABAergic synaptic maturation in rat CA1 neurons Epilepsia. 59:333-344, 2018 
• Commonalities in epileptogenic processes from different acute brain insults: Do they translate? Epilepsia. 59:37-66, 2018

2017

• Divergent brain changes in two audiogenic rat strains: A voxel-based morphometry and diffusion tensor imaging comparison of the genetically epilepsy prone rat (GEPR-3) and the Wistar Audiogenic Rat (WAR) Neurobiol Dis. 111:80-90, 2017
• Anticonvulsant effect of cannabinoid receptor agonists in models of seizures in developing rats Epilepsia. 58:1593, 2017
  
• Kappa opioid receptors regulate hippocampal synaptic homeostasis and epileptogenesis Epilepsia. 59:106-122, 2018 
  
• Redox Signaling in the Right Ventricle Adv Exp Med Biol. 2017;967:315-323
  
• Temporal Changes in Cortical and Hippocampal Expression of Genes Important for Brain Glucose Metabolism Following Controlled Cortical Impact Injury in Mice Front Endocrinol (Lausanne). 2017 Sep 11;8:231
  
• Investigating cyclic nucleotide and cyclic dinucleotide binding to HCN channels by surface plasmon resonance PLoS One. 2017 Sep 26;12(9):e0185359
  
• Disruption of perineuronal nets increases the frequency of sharp wave ripple events Hippocampus. 2017 Sep 16
  
• Inflammation alters AMPA-stimulated calcium responses in dorsal striatal D2 but not D1 spiny projection neurons Eur J Neurosci. 2017 Nov;46(9):2519-2533
  
• Angiotensin II AT2 Receptors Contribute to Regulate the Sympathoadrenal and Hormonal Reaction to Stress Stimuli Cell Mol Neurobiol. 2017 Sep 7
  
• Natural reversal of pulmonary vascular remodeling and right ventricular remodeling in SU5416/hypoxia-treated Sprague-Dawley rats PLoS One. 2017 Aug 15;12(8):e0182551
  
• A mobile APP for sharing contacts on your cell: An Editorial Highlight for ‘The physiological role of the amyloid precursor protein as an adhesion molecule in the developing nervous system’ on page 11 J Neurochem. 2017 Oct;143(1):9-10
  
• Applications of optogenetic and chemogenetic methods to seizure circuits: Where to go next? J Neurosci Res. 2017 Dec;95(12):2345-2356
  
• Morphine Withdrawal Increases Brain-Derived Neurotrophic Factor Precursor. Neurotox Res. 2017 Aug 3.
  
• Docetaxel Reverses Pulmonary Vascular Remodeling by Decreasing Autophagy and Resolves Right Ventricular Fibrosis. J Pharmacol Exp Ther. 2017 Oct;363(1):20-34
  
• Beneficial effects of Angiotensin II receptor blockers in brain disorders. Pharmacol Res. 2017 Nov;125(Pt A):91-103
  
• Human Immunodeficiency Virus Promotes Mitochondrial Toxicity. Neurotox Res. 2017 Jul 10
  
• Influence of pharmaceutical marketing on Medicare prescriptions in the District of Columbia. PLoS One. 2017 Oct 25;12(10):e0186060
  
• The stoichiometry (α4)3(β2)2 of the nicotinic acetylcholine receptor predominates in the rat motor cortex Mol Pharmacol. 92:327-337, 2017.
  
• Endocytic Trafficking of HIV gp120 is Mediated by Dynamin and Plays a Role in gp120 Neurotoxicity J Neuroimmune Pharmacol. 2017 Mar 27.
  
• Differential efficacies of the nicotinic α4β2 desensitizing agents in reducing nicotine self-administration in female rats Psychopharmacology (Berl). 2017 May 29.
  
• Cell signaling promoting protein carbonylation does not cause sulfhydryl oxidation: Implications to the mechanism of redox signaling F1000Res. 2017 Apr 10;6:455.
  
• Microglia: Housekeeper of the Central Nervous System Cell Mol Neurobiol. 2017 May 22.
  
• Oxidative profiling of the failing right heart in rats with pulmonary hypertension PLoS One. 2017 May 4;12(5):e0176887.
  
• Identification of a putative binding site critical for general anesthetic activation of TRPA1. Proc Natl Acad Sci U S A. 114:3762-3767, 2017
  
• The viral protein gp120 decreases the acetylation of neuronal tubulin: potential mechanism of neurotoxicity. J Neurochem. 141:606-613, 2017 .
  
• Polo-like kinase 2 phosphorylation of amyloid precursor protein regulates activity-dependent amyloidogenic processing. Neuropharmacology 117:387-400, 2017
  
• Blockade of glutamatergic transmission in the primate basolateral amygdala suppresses active behavior without altering social interaction. Behav Neurosci 131:192-200, 2017
  
• Pharmacist-industry relationships. Int J Pharm Pract. Jan 18, 2017
  
• Dopamine-dependent effects on basal and glutamate stimulated network dynamics in cultured hippocampal neurons. J Neurochem.140:550-560, 2017
  
• Vitamin E Nicotinate. Antioxidants (Basel). 2017 Mar 13.

2016

• Intrinsic Photosensitivity Enhances Motility of T Lymphocytes. Scientific Reports 6: 39479, 2016
• Differential stress response mechanisms in right and left ventricles. J Rare Dis Res Treat. 1:39-45, 2016
• Apoptosis-based therapy to treat pulmonary arterial hypertension. J Rare Dis Res Treat. 1:17-24, 2016
• Sex-dependent expression of TRPV1 in bladder arterioles.. Am J Physiol Renal Physiol. 311(5),2016.
• Protease induced plasticity: matrix metalloproteinase-1 promotes neurostructural changes through activation of protease activated receptor 1. Sci Rep. 6:35497, 2016.
• Treatment of Men for “Low Testosterone”: A Systematic Review. PLoS One. 11:e0162480, 2016.
• Bidirectional Control of Social Behavior by Activity within Basolateral and Central Amygdala of Primates. J Neurosci. 36:8746-56, 2016.
• Amygdala selectively modulates defensive responses evoked from the superior colliculus in non-human primates. Soc Cogn Affect Neurosci. Aug 10, 2016.
• Evidence for the role of β2* nAChR desensitization in regulating body weight in obese mice. Neuropharmacology. 110(Pt A):165-74, 2016.
• Chemogenetic silencing of the midline and intralaminar thalamus blocks amygdala-kindled seizures. Exp Neurol 283(PtA):404-412, 2016.
• Major vault protein in cardiac and smooth muscle. Receptors Clin Investig 3:pii:e1310 Epub, 2016.
• An integrative genome-wide transcriptome reveals that candesartan is neuroprotective and a candidate therapeutic for Alzheimer’s disease. Alzheimers Res Ther 8:5, 2016.
• Stress Increases GABAergic Neurotransmission in CRF Neurons of the Central Amygdala and Bed nucleus Stria Terminalis. Neuropharmacology 107:239-250, 2016.
• Anticonvulsant drug-induced cell death in the developing white matter of the rodent brain. Epilepsia 57:727-734, 2016.
• Evidence to Consider Angiotensin II Receptor Blockers for the Treatment of Early Alzheimer’s Disease. Cell Mol Neurobiol 36:259-279, 2016.
• Big Data: Challenges and opportunities for clinical pharmacology. Br J Clin Pharmacol 81:804-6, 2016.
• Direct-to-consumer Marketing to People with Hemophilia PLoS Med.13:e1001996, 2016.
• Optogenetic and pharmacological evidence that somatostatin-GABA neurons are important regulators of parasympathetic outflow to the stomach. J Physiol. 594:2661-2679, 2016.
• Carfilzomib reverses pulmonary arterial hypertension. Cardiovasc Res. Epub ahead of print, 2016.
• Comparison of the long-term behavioral effects of neonatal exposure to retigabine or phenobarbital in rats. Epilepsy Behav. 57(Pt A):34-40, 2016.
• A Mercaptoacetamide-Based Class II Histone Deacetylase Inhibitor Increases Dendritic Spine Density via RasGRF1/ERK Pathway. J Alzheimers Dis. 51:591-604, 2016.
• Neuroligin 1 regulates spines and synaptic plasticity via LIMK1/cofilin-mediated actin reorganization. J Cell Biol. 212:449-463, 2016.
• Profile of retigabine-induced neuronal apoptosis in the developing rat brain. Epilepsia Epub ahead of print, 2016.
• Expression of gp120 in mice evokes anxiety behavior: Co-occurrence with increased dendritic spines and brain-derived neurotrophic factor in the amygdala. Brain Behav Immun. pii S0889-1591(16)30021-6, 2016.
• Modulators of right ventricular apoptosis and contractility in a rat model of pulmonary hypertension. Cardiovasc Res. 110:30-39, 2016.
• Optogenetic activation of superior colliculus neurons suppresses seizures originating in diverse brain networks. Neurobiol Dis 87:102-115, 2016.
• Mapping homeostatic synaptic plasticity using cable properties of dendrites. Neuroscience 315:206-216, 2016.
• Anxiolytic- and antidepressant-like effects of the methadone metabolite 2-ethyl-5-methyl-3,3-diphenyl-1-pyrroline (EMDP). Neuropharmacology 101:46-56, 2016.
• Hexa (ethylene glycol) derivative of benzothiazole aniline promotes dendritic spine formation through the RasGRF1-Ras dependent pathway. Biochim Biophys Acta 1862:284-295, 2016.
• Major vault protein regulates cell growth/survival signaling through oxidative modifications. Cell Signal 28:12-18, 2016.
• Control of spine maturation and pruning through ProBDNF synthesized and released in dendrites. Mol Cell Neurosci 71:66-79,2016.