Barry B. Wolfe
![Barry B. Wolfe](http://sites.georgetown.edu/pharmacology/wp-content/uploads/sites/84/2019/02/bwolfe01.jpg)
Professor of Pharmacology
Ph.D., Chemistry
University of California, Santa Barbara, 1973
Office: SW-407 Med/Dent
(202) 687-1420
bwolfe01@georgetown.edu
Dr. Wolfe passed away in October of 2019. He is greatly missed. A video of our celebration of Dr. Wolfe’s is available here.
Selected Publications:
- Dalley CB, Wroblewska B, Wolfe BB, Wroblewski JT The Role of Metabotropic Glutamate Receptor 1 Dependent Signaling in Glioma Viability . J Pharmacol Exp Ther 367:59-70, 2018.
- DeDominicis KE, Sahibzada N, Olson TT, Xiao Y, Wolfe BB, Kellar KJ and Yasuda RP The stoichiometry (α4)3(β2)2 of the nicotinic acetylcholine receptor predominates in the rat motor cortex . Molecular Pharmacology July 11, 2017.
- Gelb T, Pshenichkin S, Hathaway HA, Grajkowska E, Dalley CB, Wolfe BB, Wroblewski JT. Atypical signaling of metabotropic glutamate receptor 1 in human melanoma cells. Biochem Pharmacol. doi:10.1016/j.bcp.2015.08.091, 2015.
- Tuan EW, Horti AG, Olson TT, Gao Y, Stockmeier CA, Al-Muhtasib N, Bowman Dalley C, Lewin AE,Wolfe BB, Sahibzada N, Xiao Y, Kellar KJ. AT-1001 Is a Partial Agonist with High Affinity and Selectivity at Human and Rat α3β4 Nicotinic Cholinergic Receptors. Mol Pharmacol. 88(4), 640-649, 2015.
- DiRaddo JO, Miller EJ, Bowman-Dalley C, Wroblewska B, Javidnia M, Grajkowska E, Wolfe BB, Liotta DC, Wroblewski JT. Chloride is an Agonist of Group II and III Metabotropic Glutamate Receptors. Mol Pharmacol. 88(3), 450-459, 2015.
- Hathaway HA, Pshenichkin S, Grajkowska E, Gelb T, Emery AC, Wolfe BB, Wroblewski JT. Pharmacological characterization of mGlu1 receptors in cerebellar granule cells reveals biased agonism. Neuropharmacology 93:199-208, 2015
- Gelb T, Pshenichkin S, Rodriguez O, Hathaway HA, Grajkowska E, DiRaddo JO, Wroblewska B, Yasuda R, Albanese C, Wolfe BB, Wroblewski JT. Metabotropic Glutamate Receptor 1 acts as a Dependence Receptor Creating a Requirement for Glutamate to Sustain the Viability and Growth of Human Melanomas. Oncogene, 34:2711-20, 2015
- Ullrich L, Dumanis SB, Evans TM, Jeannotte AM, Leonard C, Rozzi SJ, Taylor CM, Gale K, Kanwal JS, Maguire-Zeiss KA, Wolfe BB, Forcelli PA. From student to steward: the Interdisciplinary Program in Neuroscience at Georgetown University as a case study in professional development during doctoral training . Med Educ Online 19:22623, 2014
- Diraddo JO, Miller EJ, Hathaway HA, Grajkowska E, Wroblewska B, Wolfe BB, Liotta DC, Wroblewski JT: A Real-Time Method for Measuring cAMP Production Modulated by Gαi/o-Coupled Metabotropic Glutamate Receptors. J Pharmacol Exp Ther. 2014 Jun;349(3):373-82
- Hussmann GP, Dedominicis KE, Turner JR, Yasuda RP, Klehm J, Forcelli PA, Xiao Y, Richardson JR, Sahibzada N, Wolfe BB, Lindstrom J, Blendy JA, Kellar KJ: Chronic sazetidine-A maintains anxiolytic effects and slower weight gain following chronic nicotine without maintaining increased density of nicotinic receptors in rodent brain. J Neurochem. 2014 May;129(4):721-31
- Hussmann GP, TurnerJR, Lomazzo E, Venkatesh R, Cousins V, Xiao Y, Yasuda RP, Wolfe BB, Perry DC, Rezvani AH, Levin ED, Blendy JA, Kellar KJ: Chronic sazetidine-A at behaviorally active doses does not increase nicotinic cholinergic receptors in rodent brain . J Pharmacol Exp Ther 343:441-450, 2012
- Emery AC, Diraddo JO, Miller E, Hathaway HA, Pshenichkin S, Takoudjou GR, Grajkowska E, Yasuda RP, Wolfe BB, Wroblewski JT. Ligand Bias at Metabotropic Glutamate 1a Receptor: Molecular Determinants that Distinguish beta-arrestin from G Protein Mediated Signaling. Mol Pharmacol. May 14, 2012
- Hussmann GP, Yasuda RP, Wolfe BB, Xiao, Y, Kellar KJ Endogenously expressed muscarinic receptors in HEK293 cells augment up-regulation of stably expressed alpha4-beta2 nicotinic receptors. J Biol. Chem. 286:39726, 2011
- Lomazzo E, Hussmann GP, Wolfe BB, Yasuda RP, Perry DC, Kellar KJ Effects of chronic nicotine on heteromeric neuronal nicotinic receptors expressed in rat primary cultured neurons. J Neurochem. 119:153-164, 2011
- Lomazzo E, MacArthur L, Yasuda RP, Wolfe BB, Kellar KJ: Quantitative analysis of the heteromeric neuronal nicotinic receptors in the rat hippocampus. J Neurochem 115: 625-634, 2010
- Emery AC, Pshenichkin S, Takoudjou GR, Grajkowski E, Wolfe BB, Wroblewski JT: The protective signaling of metabotropic glutamate receptor 1 is mediated by sustained, beta-arrestin-1-dependent ERK phosphorylation. J Biol Chem 285: 26041-26048, 2010
- Mao D, Perry DC, Yasuda RP, Wolfe BB, Kellar KJ.: The alpha4beta2alpha5 nicotinic cholinergic receptor in rat brain is resistant to up-regulation by nicotine in vivo. J Neurochem. 104:446-56, 2008
- Ortinski PI, Turner JR, Barberis A, Motamedi G, Yasuda RP, Wolfe BB, Kellar KJ, Vicini S.: Deletion of the GABA(A) receptor alpha1 subunit increases tonic GABA(A) receptor current: a role for GABA uptake transporters. J Neurosci. 26:9323, 2006
- Lu C, Fu Z, Karavanov I, Yasuda RP, Wolfe BB, Buonanno A, Vicini S.: NMDA receptor subtypes at autaptic synapses of cerebellar granule neurons. J Neurophysiol. 96:2282-94, 2006
- Mao D, Yasuda RP, Fan H, Wolfe BB, Kellar KJ.: Heterogeneity of nicotinic cholinergic receptors in rat superior cervical and nodose Ganglia. Mol Pharmacol. 70:1693-9, 2006
- Marritt AM, Cox BC, Yasuda RP, McIntosh JM, Xiao Y, Wolfe BB, Kellar KJ.: Nicotinic cholinergic receptors in the rat retina: simple and mixed heteromeric subtypes. Mol Pharmacol. 68:1656-1668, 2005
- Brown KM, Wolfe BB, Wrathall JR.: Rapid functional recovery after spinal cord injury in young rats. J Neurotrauma. 22:559-574, 2005
- Brown KM, Wrathall JR, Yasuda RP, Wolfe BB.: Glutamate receptor subunit expression after spinal cord injury in young rats. Brain Res Dev Brain Res. 152:61-68, 2004
- Jarabek BR, Yasuda RP, Wolfe BB.: Regulation of proteins affecting NMDA receptor-induced excitotoxicity in a Huntington’s mouse model. Brain 127: 505-516, 2004
- Carter TL, Rissman RA, Mishizen-Eberz AJ, Wolfe BB, Hamilton RL, Gandy S, Armstrong DM.: Differential preservation of AMPA receptor subunits in the hippocampi of Alzheimer’s disease patients according to Braak stage. Experimental Neurology, 187:299-309, 2004
- Mishizen-Eberz AJ, Rissman RA, Carter TL, Ikonomovic MD, Wolfe BB, Armstrong DM.: Biochemical and molecular studies of NMDA receptor subunits NR1/2A/2B in hippocampal subregions throughout progression of Alzheimer’s disease pathology. Neurobiol Dis 15: 80-92, 2004
- Rissman RA, Mishizen-Eberz AJ, Carter TL, Wolfe BB, De Blas AL, Miralles CP, Ikonomovic MD, Armstrong DM.: Biochemical analysis of GABA(A) receptor subunits alpha 1, alpha 5, beta 1, beta 2 in the hippocampus of patients with Alzheimer’s disease neuropathology. Neurosci 120:695-704,2003
- Al-Hallaq RA, Jarabek BR, Fu Z, Vicini S, Wolfe BB, Yasuda RP.: Association of NR3A with the N-methyl-D-aspartate receptor NR1 and NR2 subunits. Mol Pharmacol 62:1119-1127, 2002
- Brown KM, Wrathall JR, Yasuda RP, Wolfe BB.: Quantitative measurement of glutamate receptor subunit protein expression in the postnatal rat spinal cord. Dev Brain Res 137: 127-133, 2002
- Yeh J, Ferreira M, Ebert S, Yasuda RP, Kellar KJ, Wolfe BB.: Axotomy and nerve growth factor regulate levels of neuronal nicotinic acetylcholine receptor alpha3 subunit protein in the rat superior cervical ganglion. J Neurochem 79:258-265, 2001
- Al-Hallaq RA, Yasuda RP, Wolfe BB.: Enrichment of N-methyl-D-aspartate NR1 splice variants and synaptic proteins in rat postsynaptic densities. J Neurochem 77:110-119, 2001
- Yeh JJ, Yasuda RP, Dávila-García MI, Xiao Y, Ebert S, Gupta T, Kellar KJ, Wolfe BB.: Neuronal nicotinic acetylcholine receptor alpha3 subunit protein in rat brain and sympathetic ganglion measured using a subunit-specific antibody: regional and ontogenic expression. J Neurochem 77:336-346, 2001
- Adams MM, Smith TD, Moga D, Gallagher M, Wang Y, Wolfe BB, Rapp PR, Morrison JH.: Hippocampal dependent learning ability correlates with N-methyl-D-aspartate (NMDA) receptor levels in CA3 neurons of young and aged rats. J Comp Neurol 432:230-243, 2001
- Prybylowski KL, Grossman SD, Wrathall JR, Wolfe BB.: Expression of splice variants of the NR1 subunit of the N-methyl-D-aspartate receptor in the normal and injured rat spinal cord. J Neurochem 76:797-805, 2001
- Prybylowski KL, Wolfe BB.: Developmental differences in alternative splicing of the NR1 protein in rat cortex and cerebellum. Dev Brain Res 123:143-150, 2000
- Wang Y, TesFaye E, Yasuda RP, Mash DC, Armstrong DM, Wolfe BB.: Effects of post-mortem delay on subunits of ionotropic glutamate receptors in human brain. Mol Brain Res 80:123-131, 2000
- Prybylowski K, Rumbaugh G, Wolfe BB, Vicini S.: Increased exon 5 expression alters extrasynaptic NMDA receptors in cerebellar neurons. J Neurochem 75:1140-1146, 2000
- Grossman SD, Wolfe BB, Yasuda RP, Wrathall JR.: Changes in NMDA receptor subunit expression in response to contusive spinal cord injury. J Neurochem 75:174-184, 2000
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