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An explanation of the plants used in this
site...
Amanita muscaria (Fly Agaric),
seminars
The Fly Agaric is a source of muscimol, thought to have
psychotropic activity. Muscimol is an agonist at GABAA
receptors which transmit inhibitory signals in the brain. This
mushroom also is a source of muscarine, the drug that defined the muscarinic
acetylcholine receptor, important for the parasympathetic control of most
organs of the body.
Atropa belladonna (Deadly Nightshade), homepage
Atropine, one of the most important pharmaceuticals ever discovered, is derived
from the Deadly Nightshade. It was named for the Greek Atropos, one of the
Fates that cut the threads of human life. Belladonna refers to the Italian
women who would use deadly nightshade to "brighten" their eyes by dilating the
pupils. It does this by antagonizing the action of acetylcholine at
muscarinic acetylcholine receptors.
Coca is the plant that is used to produce cocaine, an historic anesthetic
and drug of addiction. Cocaine is thought to act mainly by inhibiting
the uptake of synaptically released dopamine into nerve terminals, thus
prolonging the synaptic effects of this neurotransmitter.
Nicotiana tabacum (Tobacco), faculty page
Tobacco is a major agricultural product grown throughout the world. Since the colonization of North America
tobacco has become one of the world's largest and most lucrative harvests.
Tobacco leaves are the source of the drug nicotine whose specific action to
stimulate the nicotinic acetylcholine receptors found in striated muscle,
autonomic ganglia, and the CNS, gave them their name.
Papaver somniferum (Opium Poppy),
courses page
Opium, named for the Greek word opos, meaning juice, is derived from the
seed pod of the Opium Poppy. Morphine and codeine, two drugs widely used
to control pain, are derived from the opium poppy. These drugs are
agonists at various opioid receptors in the brain.
Physostigma venenosum (Calabar Bean),
admissions page
The calabar bean comes from Old Calabar, West Africa where it is known as
the Ordeal Bean. The beans were used by natives as a test of innocence
or guilt; the guilty would die after injesting the bean. The calabar
bean is used to produce the toxin physostigmine, a very useful tool in
modern day science. Physostigmine acts as an inhibitor of
acetylcholinesterase, the enzyme that terminates the synaptic action of
acetylcholine. By inhibiting the enzyme, the action of acetylcholine
is prolonged.
Strychnos ignatii (St. Ignatius bean),
courses
page
The St. Ignatius Bean is native to the Phillipines, but was named for Jesuits in
Cochin China that studied this plant. At one time, it was thought that the Strychnos species could be used to treat cholera. Its importance to
Pharmacology is the chemical derivative, strychnine. Strychnine was
discovered in 1818 by French Chemists Joseph-Bienaime Caenoin and Pierre-Joseph
Pelletier, and is still in use today. Strychnine is an antagonist of the
actions of glycine which is a major inhibitory neurotransmitter in the brain.
Information taken from:
http://botanical.com, a modern herbal
guide
http://bltc.com, a site dedicated to
paradise-engineering
http://www.thinkquest.org, poisonous
plants and animals website
http://www.lycaeum.org/
Other informative botanical links:
The Urban Herb, a guide to the plantlife around campus (sponsored by CAM)
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