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Bidhan C. Bandyopadhyay
Adjunct Professor of Pharmacology and Physiology
Ph.D., Biochemistry
University of Calcutta, 1998
bcb@georgetown.edu
Principal Investigator
Calcium Signaling Laboratory
Research Service (151)
DVA Medical Center
50 Irving Street, NW
Washington, DC 20422
Phone:202-745-8622
Fax: 202-462-2006
bidhan.bandyopadhyay@va.gov
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Major
focus of my laboratory at the Department of Veterans Affair Medical Center,
Washington DC is to understand the mechanism of Ca2+
signaling/transport in kidney and salivary gland epithelial cells using genetic,
pharmacological, and translational approaches. Our long-term goal is to
understand the implications of these mechanisms in calcium stone disease and
biomineralization. Presently, we are utilizing a variety of approaches (such as
biochemistry and molecular biology as well as physiology) to determine whether
the TRPC sub-families of ion channel proteins are involved in
regulating/mediating Ca2+ transport in these epithelial cells. Our
research program can provide research training to the residents/students of
Pharmacology, Otolaryngology and Renal Division. We are currently funded by NIH
and NKF to continue the following projects. Project 1: Mechanism of Ca2+
transports in the kidney proximal tubule and its implication for calcium
nephrolithiasis; funded by NKF. Project 2: Mechanisms of salivary ductal Ca2+
signaling and its role in stone formation; funded by NIH.
Selected Publications:
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Bandyopadhyay BC, Pingle SC and Ahern GP.
Store-operated Ca2+ signaling in dendritic cells occurs independently of
STIM1. Journal of Leukocyte Biology. 89.1: 57-62, 2011
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Bandyopadhyay BC, Ong HL, Lockwich TP, Liu X, Paria BC, Singh
BB, Ambudkar IS.
TRPC3 controls agonist-stimulated intracellular Ca2+ release by mediating
interaction between IP3R and RACK1. Journal of Biological Chemistry.
283.47:32821-30, 2008
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Liu X, Cheng KT, Bandyopadhyay BC, Pani B, Dietrich A, Paria
BC, Swaim WD, Beech D, Yildrim E, Singh BB, Birnbaumer L, Ambudkar IS.
Attenuation of store-operated Ca2+ current impairs salivary gland fluid
secretion in TRPC1(-/-) mice. Proc Natl Acad Sci U S A. 104.44:
17542-7,
2007
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Liu X, Bandyopadhyay BC, Nakamoto T, Singh B, Liedtke W,
Melvin JE, Ambudkar I.
A role for AQP5 in activation of TRPV4 by hypotonicity: concerted
involvement of AQP5 and TRPV4 in regulation of cell volume recovery.
Journal of Biological Chemistry. 281.22:15485-95,
2006
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Bandyopadhyay BC, Liu X, Singh BB, Groschner K, Ambudkar IS.
Molecular analysis of a store-operated and 2-acetyl-sn-glycerol-sensitive
non-selective cation channel. Heteromeric assembly of TRPC1-TRPC3.
Journal of Biological Chemistry. 280.22:21600-6,
2005
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Bandyopadhyay BC, Swaim WD, Liu X, Redman RS, Patterson RL,
Ambudkar IS.
Apical localization of a functional TRPC3/TRPC6-Ca2+-signaling complex in
polarized epithelial cells. Role in apical Ca2+ influx. Journal of
Biological Chemistry. 280.13:12908-16,
2005
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Tran SD, Bandyopadhyay BC, Wang J, Redman RS, Dutra A, Pak E,
Swaim WD, Gerstenhaber JA, Bryant JM, Zheng C, Goldsmith CM, Kok MR, Wellner
RB, Baum BJ.
Primary culture of polarized human salivary epithelial cells for use in
developing an artificial salivary gland. Tissue Eng.
11.1-2:172-81,
2005
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Bandyopadhyay BC, Payne R.
Variants of TRP ion channel mRNA present in horseshoe crab ventral eye and
brain. J Neurochem. 91.4:825-35,
2004
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Singh BB, Lockwich TP, Bandyopadhyay BC, Liu X, Bollimuntha
S, Brazer SC, Combs C, Das S, Leenders AG, Sheng ZH, Knepper MA, Ambudkar SV,
Ambudkar IS.
VAMP2-dependent exocytosis regulates plasma membrane insertion of TRPC3
channels and contributes to agonist-stimulated Ca2+ influx. Molecular
Cell 15.4:635-46,
2004
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Kozikowski AP, Johnson KM, Deschaux O, Bandyopadhyay BC,
Araldi GL, Carmona G, Munzar P, Smith MP, Balster RL, Beardsley PM, Tella
SR.
Mixed cocaine agonist/antagonist properties of (+)-methyl
4beta-(4-chlorophenyl)-1-methylpiperidine-3alpha-carboxylate, a piperidine-based
analog of cocaine. J Pharmacol Exp Ther. 305.1:143-50,
2003
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Tamiz AP, Bandyopadhyay BC, Zhang J, Flippen-Anderson JL,
Zhang M, Wang CZ, Johnson KM, Tella S, Kozikowski AP.
Pharmacological and behavioral analysis of the effects of some bivalent
ligand-based monoamine reuptake inhibitors. J Med Chem.
44.10:1615-22,
2001
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