Faculty

David Gortler's research examines atherosclerosis, atheroprogression, cholesterol metabolism (including: statin pharmacology and lipid/ LDL/ HDL modulation) and obesity. Dr. Gortler is proficient in the drug development process, the drug approval process, clinical trial design, and is a drug expert and an expert in the FDA review process. Among other reviews, Dr. Gortler was the lead FDA expert and lead clinical reviewer for the Merck SEARCH Trial which compared the safety and efficacy of simvastatin 80mg to simvastatin 20mg. Prior to joining Georgetown, Dr. Gortler was an Assistant Professor of Pharmacology at Yale University, and prior to that he was an Investigational Medicine Scientist at Pfizer Inc.

Plaque Obstructed Coronary Artery          Patient Coronary Artery              

Selected Publications:

• Gortler D, Schlösser FJ, Muhs BE, Nelson MA, Dardik A. Periprocedural drug therapy in carotid artery stenting: the need for more evidence. Vascular. 16(6):303-9, 2008

• Gortler D, Maloney S, Rutland R, Westvik T, Muto A, Kudo FA, Dardik A. Adjunctive pharmacologic use in carotid endarterectomy: a review. Vascular. 14(2):93-102, 2006

• Haga M, Chen A, Gortler D, Dardik A, Sumpio BE. Shear stress and cyclic strain may suppress apoptosis in endothelial cells by different pathways. Endothelium. 10(3):149-57, 2003

• Kilaru S, Frangos SG, Chen AH, Gortler D, Dhadwal AK, Araim O, Sumpio BE. Nicotine: a review of its role in atherosclerosis. J Am Coll Surg. 193(5):538-46, 2001

• Chen AH, Gortler DS, Kilaru S, Araim O, Frangos SG, Sumpio BE. Cyclic strain activates the pro-survival Akt protein kinase in bovine aortic smooth muscle cells. Surgery. 130(2):378-81, 2001

Medline Publications and Articles: 

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