Professor of Pharmacology
University of Washington, 1975
Dr. Karen Gale passed away on August 21st, 2014.
A memorial service was held on
Sunday, September 21, 2014 at 1:00 pm.
Copley Formal Lounge in Copley Hall
Gifts to help found "The Karen Gale Memorial Lecture for Women in Neuroscience" can be sent
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P.O. Box 571253
Washington, D.C. 20057-1253
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(a) Go to giving.georgetown.edu
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The Karen Gale Memorial Lectureship For Outstanding Women in Neuroscience
October 27th 2015 at 3:30-4:30pm in the New Research Building Auditorium
It is our pleasure to have Dr. Helen Scharfman, Professor of Psychiatry, Neuroscience, and Physiology at New York University and the Nathan Kline Institute deliver the inaugural lecture, entitled, “Diverse roles of neurogenesis in the adult brain and in disease”. Dr. Scharfman is a world-recognized expert in epilepsy, neurogenesis, hippocampal physiology, and neurotrophins. In addition to her scientific excellence, Dr. Scharfman is a dedicated mentor. We can think of no one that better embodies the spirit of this lectureship than Dr. Scharfman.
Dr. Karen Gale joined the faculty at Georgetown in 1977, and quickly rose through the ranks in the Department of Pharmacology & Physiology, where she was a full professor for over 25 years. Dr. Gale was a world-recognized leader in the field of epilepsy, and published over 200 papers in her career.
She made seminal contributions to the understanding of neural circuitry that controls seizure propagation, mechanisms of seizure-induced neuroprotection and damage, and effects of early life exposure to anticonvuslant drugs. Dr. Gale’s research was the first to identify the crucial role of basal ganglia nuclei in the control of epilepsy, as well as the role of a region of the piriform cortex, dubbed “Area Tempestas” in the genesis of seizures.
In addition to her scientific achievements, Dr. Gale was a stalwart advocate for trainees, early career investigators, minority scientists, and women scientists. One of Dr. Gale’s most lasting contributions to Georgetown was serving as the founding director of the Interdisciplinary Program in Neuroscience from 1994-2003. Her continued leadership over the next 11 years helped shape the IPN into not only a world-class training program, but a community cultivated through thoughtful and deliberate action.
In recognition of her advocacy and passion for the advancement of women in science, her family and close colleagues endow this lectureship, with funding generously provided by by the Office of the President at Georgetown University, The American Epilepsy Society, and the Society for Neuroscience.
The Karen Gale Memorial Lectureship for Outstanding Women in Neuroscience will be held annually through the Interdisciplinary Program in Neuroscience and the Department of Pharmacology & Physiology at Georgetown University Medical Center. We will recognize each year a female scientist who has made outstanding contributions to the field, both in the laboratory and through mentorship.
In recognition of Dr. Gale’s belief that graduate trainees should be actively involved in leadership, the selection committee includes two doctoral trainees each from the Interdisciplinary Program in Neuroscience and Department of Pharmacology & Physiology. These trainees will serve on the selection and organizing committee with two faculty selected from each program.
Dr. Gale's laboratory research projects focused on specific neural networks in the brain and their role in neurological disorders. Special attention was devoted to the limbic system and the basal ganglia, with respect to glutamate and GABA-mediated influences on epileptic seizures and memory. Neural substrates of Parkinsonism and cocaine-induced hyperkinesias were also studied.
- Vismer MS, Forcelli PA, Skopin MD, Gale K, Koubeissi MZ: The piriform, perirhinal, and entorhinal cortex in seizure generation.. JFront Neural Circuits. 2015 May 29;9:27
- Malkova L, Forcelli PA, Wellman LL, Dybdal D, Dubach MF, Gale K.Blockade of glutamatergic transmission in perirhinal cortex impairs object recognition memory in macaques. J Neurosci. 2015 Mar 25;35(12):5043-50.
- Gutherz SB, Kulick CV, Soper C, Kondratyev A, Gale K, Forcelli PA.Brief postnatal exposure to phenobarbital impairs passive avoidance learning and sensorimotor gating in rats Epilepsy Behav. 37C:265-269, 2014
- Ullrich L, Dumanis SB, Evans TM, Jeannotte AM, Leonard C, Rozzi SJ, Taylor CM, Gale K, Kanwal JS, Maguire-Zeiss KA, Wolfe BB, Forcelli PA: From student to steward: the Interdisciplinary Program in Neuroscience at Georgetown University as a case study in professional development during doctoral training. Med Ed Online 19:22623, 2014
- Forcelli PA, Palchik G, Leath T, Desjardin JT, Gale K, Malkova L: Memory loss in a nonnavigational spatial task after hippocampal inactivation in monkeys. Proc Natl Acad Sci U S A. 2014 Mar 18;111(11):4315-20
- Forcelli PA, Kalikhman D, Gale K: Delayed effect of craniotomy on experimental seizures in rats. PLoS One. 2013 Dec 4;8(12):e81401
- Forcelli PA, Soper C, Duckles A, Gale K, Kondratyev A: Melatonin potentiates the anticonvulsant action of phenobarbital in neonatal rats. Epilepsy Res. 2013 Dec;107(3):217-23
- DesJardin JT, Holmes AL, Forcelli PA, Cole CE, Gale JT, Wellman LL, Gale K, Malkova L: Defense-like behaviors evoked by pharmacological disinhibition of the superior colliculus in the primate. J Neurosci 33:150-155, 2013
- Dybdal D, Forcelli PA, Dubach M, Oppedisano M, Holmes A, Malkova L, Gale K: Topography of dyskinesias and torticollis evoked by inhibition of substantia nigra pars reticulata. Mov Disord Oct 31 epub, 2012
- Holmes AL, Forcelli PA, Desjardin JT, Decker AL, Teferra M, West EA, Malkova L, Gale K: Superior colliculus mediates cervical dystonia evoked by inhibition of the substantia nigra pars reticulata. J Neurosci 32:13326, 2012
- West EA, Forcelli PA, Murnen AT, McCue DL, Gale K, Malkova L. Transient inactivation of basolateral amygdala during selective satiation disrupts reinforcer devaluation in rats. Behav Neurosci 126:562, 2012
- Forcelli PA, Kozlowski R, Snyder C, Kondratyev A, Gale K. Effects of neonatal antiepileptic drug exposure on cognitive, emotional, and motor function in adult rats. J Pharmacol Exp Ther 340:558, 2012
- Forcelli PA, Kim J, Kondratyev A, Gale K. Pattern of antiepileptic drug-induced cell death in limbic regions of the neonatal rat brain. Epilepsia 52:e207, 2011
- West EA, Desjardin JT, Gale K, Malkova L. Transient inactivation of orbitofrontal cortex blocks reinforcer devaluation in macaques. J Neurosci 31:15128-35, 2011
- Crowe SL, Tsukerman S, Gale K, Jorgensen TJ, Kondratyev AD. Phosphorylation of histone H2A.X as an early marker of neuronal endangerment following seizures in the adult rat brain. J Neurosci. 31(21):7648-56, 2011
- Forcelli PA, Gale K, Kondratyev A. Early postnatal exposure of rats to lamotrigine, but not phenytoin, reduces seizure threshold in adulthood. Epilepsia. 52:E20-2, 2011.
- Malkova L, Kozikowski AP, Gale K. The effects of huperzine A and IDRA 21 on visual recognition memory in young macaques. Neuropharmacology60:1262, 2011
- West EA, Forcelli PA, Murnen A, Gale K, Malkova L. A visual, position-independent instrumental reinforcer devaluation task for rats. J Neurosci Methods194:297, 2011
- Besio WG, Gale KN, Medvedev AV. Possible therapeutic effects of transcutaneous electrical stimulation via concentric ring electrodes.Epilepsia.51:85-7, 2010
- Forcelli PA, Janssen MJ, Stamps LA, Sweeney C, Vicini S, Gale K. Therapeutic strategies to avoid long-term adverse outcomes of neonatal antiepileptic drug exposure. Epilepsia. 51:18-23,2010
- Kim J, Gale K, Kondratyev A. Effects of repeated minimal electroshock seizures on NGF, BDNF and FGF-2 protein in the rat brain during postnatal development. Int J Dev Neurosci. 28:227-32, 2010
- Conti G, Gale K, Kondratyev A: Immunohistochemical evaluation of the protein expression of nerve growth factor and its TrkA receptor in rat limbic regions following electroshock seizures. Neurosci Res. 2009.
- Kim JS, Kondratyev A, Tomita Y, Gale K. Neurodevelopmental impact of antiepileptic drugs and seizures in the immature brain. Epilepsia. 48:19-26, 2007
- Kim J, Kondratyev A, Gale K. Antiepileptic drug-induced neuronal cell death in the immature brain: effects of carbamazepine, topiramate, and levetiracetam as monotherapy versus polytherapy. J Pharmacol Exp Ther. 323:165-73, 2007
- Katz I, Kim J, Gale K, Kondratyev A. Effects of lamotrigine alone and in combination with MK-801, phenobarbital, or phenytoin on cell death in the neonatal rat brain. J Pharmacol Exp Ther. 322:494-500, 2007
- Wellman LL, Gale K, Malkova L. GABAA-mediated inhibition of basolateral amygdala blocks reward devaluation in macaques. J Neurosci. 25:4577-86, 2005
- Fornai F, Busceti CL, Kondratyev A, Gale K. AMPA receptor desensitization as a determinant of vulnerability to focally evoked status epilepticus. Eur J Neurosci. 21:455-63, 2005
- Kondratyev A, Gale K. Latency to onset of status epilepticus determines molecular mechanisms of seizure-induced cell death. Brain Res Mol Brain Res. 121:86-94, 2004
- Richardson KA, Gluckman BJ, Weinstein SL, Glosch CE, Moon JB, Gwinn RP, Gale K, Schiff SJ. In Vivo Modulation of Hippocampal Epileptiform Activity with Radial Electric Fields. Epilepsia 44:768-777, 2003
- Kondratyev A, Ved R, Gale K. The effects of repeated minimal electroconvulsive shock exposure on levels of mRNA encoding fibroblast growth factor-2 and nerve growth factor in limbic regions. Neuroscience 114:411-416, 2003
- Gwinn RP, Kondratyev A, Gale K. Time-dependent increase in basic fibroblast growth factor protein in limbic regions following electroshock seizures. Neuroscience 114:403-409, 2002
- Kondratyev A, Selby D, Gale K. Status epilepticus leads to the degradation of the endogenous inhibitor of caspase-activated DNase in rats. Neurosci Lett 319:145-148, 2002
- Kondratyev A, Gale K. Temporal and spatial patterns of DNA fragmentation following focally or systemically-evoked status epilepticus in rats. Neurosci Lett. 310:13-16, 2001
- Kondratyev A, Sahibzada N, Gale K. Electroconvulsive shock exposure prevents neuronal apoptosis after kainic acid-evoked status epilepticus. Brain Res Mol Brain Res. 91:1-13, 2001
- Dybdal D, Gale K. Postural and anticonvulsant effects of inhibition of the rat subthalamic nucleus. J Neurosci. 20:6728-33, 2000
- Doherty J, Gale K, Eagles DA. Evoked epileptiform discharges in the rat anterior piriform cortex: generation and local propagation. Brain Res.
- Kondratyev A, Gale K. Intracerebral injection of caspase-3 inhibitor prevents neuronal apoptosis after kainic acid-evoked status epilepticus. Brain Res Mol Brain Res. 75:216-24, 2000
- Walker BR, Easton A, Gale K. Regulation of limbic motor seizures by GABA and glutamate transmission in nucleus tractus solitarius. Epilepsia. 40:1051-7, 1999
- Masco D, Sahibzada N, Switzer R, Gale K. Electroshock seizures protect against apoptotic hippocampal cell death induced by adrenalectomy. Neurosciencee.
- New KC, Gale K, Martuza RL, Rabkin SD. Novel synthesis and release of GABA in cerebellar granule cell cultures after infection with defective herpes simplex virus vectors expressing glutamic acid decarboxylase. Brain Res Mol Brain Res. 61:121-35, 1998
- Cassidy RM, Gale K. Mediodorsal thalamus plays a critical role in the development of limbic motor seizures. J Neurosci. 18:9002-9, 1998
- Tortorella A, Halonen T, Sahibzada N, Gale K. A crucial role of the alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid subtype of glutamate receptors in piriform and perirhinal cortex for the initiation and propagation of limbic motor seizures. J Pharmacol Exp Ther. 280:1401-5, 1997