TRP channels
Transient Potential Receptors or "TRPs" are an important class of ion channels widely expressed in mammalian tissues. Our laboratory studies the regulation of TRP channels and their biological roles in physiology and disease. We employ a range of electrophysiological, imaging, molecular and behavioral techniques.
A major focus of study is the capsaicin receptor (TRPV1), an ion channel that plays a pivotal role in pain signaling. We investigate the molecular signals that control TRPV1 function. Our laboratory has identified several novel agonists and activation mechanisms for this receptor. In addition, we have identified a new role for TRPV1 in the regulation of feeding and body weight.
