TBIO508 - Cellular and Molecular Aspects of the Transformed Cell

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  Tumor biology I: cellular and molecular aspects of the transformed cell

tBio-508 (4 Credits)

2009 fall schedule

course directors: dr. anna riegel &  Michael johnson

tuesday, thursday, friday 3:30-4:30, W302, the research building

1.                  carcinogenesis and dna repair
SECTIOn Leader: Chung

SEP    3          metabolic activation and detoxification of carcinogens (roy)
sep    4          dna adduct formation and its consequences (Chung)
sep    8          dna repair and mutagenesis (roy)
sep    10        viral carcinogenesis I (schlegel)
sep    11        viral carcinogenesis II (schlegel)
sep    15        An overview of environmental causes of human cancer (Rice)

2.                  genetics and cytogenetics
section leader: blancato

SEP 17       knudsen; principles of single gene inheritance; genetic disorders/ family cancer syndrome
                  (blancato)
sep    18        cancer cytogenetics (blancato)
sep    22        genetics of hematologic malignancy/vogelstein science  (toretsky)
sep    24        genetics of breast cancer, brca (rosen) 

3.                  cell cycle and apoptosis
section leader: furth/Bae

Sep 25         definitions of apoptosis and senescence; biomarkers of apoptosis vs. senescence (Bae)                                 sep    29        introduction to the cell cycle, survey of oncogenes and tumor supressors in the cell cyclE
                  (albanese)
oct    1          cancer stem cells (fitzgerald)
oct    2          apoptosis: intrinisic (mitochondrial) pathway (DEB)
oct    6          apoptosis: extrinsic pathway (bae) 

4.                  oncogene
section leader: avantaggiatti

oct    8          introduction, criteria/experimental evaluation of tumor suppressor and oncogene (tomita)                                  

oct    9          exam (section 1 +2)    

oct    13        apc and Cancer (uren)
oct    15        tumor supressors and control of the cell cycle; p53  (avantaggiatti) 
Oct    16        tumor supressors and maintenance of genomic stability  (avantaggiatti)
oct    20        ras (notario)
oct    22       pten/p13K (Waldman)

5.                  invasion, metastasis and angiogenesis
section leader: wellstein   

oct    23        mETASTASIS/ METASTASIS SUPPRESSOR GENES/IMAGING (MUELLER)
oct    27        CELLULAR MECHANISMS OF INVASION (MUELLER)
oct    29        SRC TYROSINE KINASE (MUELLER)
OCT    30        ANGIOGEN-1 (WELLSTEIN)
NOV    3          ANGIOGEN-2 (WELLSTEIN)
NOV    5          Open (study Time)
NOV    6          Senescence (Furth)      
NOV    10        Apoptosis: ROLE of apoptosis in cancer Development and Therapeutic Response (Furth)

6.                  ENDOCRINOLOGY AND GROWTH FACTORS
SECTION LEADER: CLARKE

NOV    12        NUCLEAR HORMONE RECEPTOR SIGNALING (ROSEN)
NOV    13        ESTROGEN AND BREAST CANCER (CLARKE)
NOV    17        STEROID HORMONE BIOSYNTHESIS AND CANCER (CLARKE)
NOV    19       GROWTH FACTORS, PEPTIDE HORMONES AND CANCER: LEPTINS, IGF (HILAKIVI-CLARKE)
NOV    20        GROWTH FACTORS AND CANCER- THE EGFR SUPERFAMILY (TANG)

NOV    24        Exam (Sections 3 +4)

NOV   26        THANKSGIVING HOLIDAY
NOV   27        THANKSGIVING HOLIDAY

7.                  IMMUNOLOGY
SECTION LEADER: HURLEY

DEC   1          KEY IMMUNOLOGY CONCEPTS (HURLEY)
DEC   3          CANCER IMMUNOLOGY-ADAPTIVE IMMUNE RESPONSE (HURLEY)
DEC  4          CANCER IMMUNOLOGY- INNATE RESPONSE & TUMOR ESCAPE (POSCH)     

DEC   8          Exam (Sections 5, 6, + 7)

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