Pharmacology 588
Tuesday and Thursday: 5:00-6:30pm, Med-Dent Bldg, NE403 3 Credits
Instructors
Summer Rozzi Kathol sjr65@georgetown.edu
Carrie Leonard cel72@georgetown.edu
Office Hours: By Appointment
I. Rationale
This course is designed for students with an interest in brain function and dys- (or altered) function, as well as brain pharmacology
II. Course Aims and Objectives
Aims
To familiarize students with the science of the diseases and disorders that affect brain function and behavior, as well as the relevant pharmacology.
Specific Learning Objectives:
By the end of this course, students will have:
- factual knowledge about normal functioning of the brain as it relates to specific diseases/disorders
- basic mechanisms of neural function and dysfunction
- clinical presentations of nervous system diseases
- treatment options and mechanisms of therapeutic action
- the ability to knowledgeably discuss and critique papers
- the ability to weigh the value and validity of different animal models of disease
- the ability to weigh the pros and cons of competing theories
- familiarity with the wide variety of methods used in neuroscience research.
- an understanding of pharmacology as both a tool to explore and a therapy to treat brain dysfunction.
III. Format and Procedures
This course meets twice a week. Classes will alternate between lectures in which new material will be presented and a paper discussions, in which students will lead a critical analysis of a paper(s) relevant to the preceding lecture
IV. Course Requirements
1. Class attendance and participation policy:
Attendance and participation are mandatory. You are expected to participate in both the lectures (by asking questions and answering questions) and the paper discussions (by leading discussions and asking questions during discussions you are not leading). While attendance and participation will not be averaged into your grade, they will be taken into account when determining your final grade in the class (e.g., the difference between an A and A-, or B and B+ when your grade is borderline).
2. Course readings:
The course schedule lists readings posted to the course blackboard website. In addition to background readings (due the day of class), there will be articles for discussion (due the day prior to presentation). You are responsible for the knowing the information in the readings. Before every paper discussion, students not responsible for leading the discussion must submit 2 questions about the paper by 9am on the day prior to the presentation. Late questions will be given half-credit if submitted within one week of the presentation. Questions must be submitted via the course Blackboard site (campus.georgetown.edu).
V. Grading Procedures
Midterm Examination = 30%
inal Examination = 30%
Presentation(s) = 30%
Paper Questions = 10%
The lowest grade out of the midterm, final, and paper presentation grades may be replaced by an optional term paper (details below).
Term Paper An optional paper on a topic of your choosing, which must be focused on a dysfunction or disease covered in class. You must get approval of your topic from an instructor beforehand, no later than 4/15. When you bring your topic for approval, please come prepared with a preliminary thesis statement and 1-page outline incorporating at least 3 primary sources (not including review articles). The paper is due the same day as the final exam.
Your paper must be at least 8 pages in length and must include at least 8 primary sources not used in class (n.b. this does not include review articles). If you have questions about appropriate sources, please ask an instructor.
VI. Academic Integrity
Each student in this course is expected to abide by the Georgetown University Honor Pledge. Any work submitted by a student in this course for academic credit will be the student’s own work. Any violation of the Honor Pledge will result in no credit for the given assignment and automatic reporting of the violation to the Honor Council.
VII. Presentation Grading Rubric
Background |
Presents previous research on this topic and why the study was done. |
__/10 |
General aims and hypotheses |
Explains the questions the authors are asking and what they thought they would find based on previous research. |
__/5 |
Figures |
__/45 | |
Experimental aims and hypotheses |
Explains the questions the authors are asking with each figure and what they thought they would find based on previous research. |
__/10 |
Methods |
Explains methods clearly and demonstrates basic understanding of how they work. |
__/10 |
Explains figure |
Explains axes of graphs, labels, experimental groups, scale, etc. |
__/10 |
Results and conclusions |
Explains the results of each figure and how the conclusions follow from them. Points out significant differences. |
__/10 |
Transition to next experiment |
Explains how one figure leads to the next and how the experiments fit together. |
__/5 |
Conclusions |
Explains the overall conclusions of the paper. |
__/5 |
Future directions |
Outlines several experiments that logically follow from this paper, or experiments that should be done to fill in the gaps in this paper |
__/5 |
Strengths and weaknesses |
Points out strengths and weaknesses of the paper. |
__/10 |
Knowledge |
Demonstrates fluency in the paper through competence answering questions and making educated guesses. |
__/10 |
Presentation style |
Presentation is clear and well-organized. Speaks loudly and confidently. Includes key figures in presentation. |
__/10 |
Total __/100 |
VII. Class Schedule 2011
Date | Topic | Lecturer |
Sept. 1st |
Introduction |
Dumanis/Krafnick/Connor/Azma |
Sept. 6th |
Introduction: How To Present A Paper |
Queenan/Dumanis/Krafnick/Connor/Azma |
Sept. 8th |
Homeostasis and Stress |
Forcelli |
Sept 13th |
Reward and Addiction |
Tuan |
Sept. 15th |
Reward and Addiction (cont.), Paper Presentation |
Pepe |
Sept. 20th |
Reward and Addiction (cont.) |
Pepe |
Sept. 22nd |
Ingestive Behavior |
TBD |
Sept. 27th |
Eating Disorders, Paper Presentation |
Orefice |
Sept. 29th |
Neural Circuits of Mood Regulation, Major Depressive Disorder |
Krafnick |
Oct. 4th |
Major Depressive Disorder (cont.), Paper Presentation |
Krafnick |
Oct. 6th |
Anxiety Disorders |
Azma |
Oct. 11th |
Bipolar Disorder, Paper Presentation |
Shattuck |
Oct. 13th |
OCD, Executive Function |
Pepe, Gordon |
Oct. 18th |
Executive Function (cont.), Schizophrenia |
Gordon, Krafnick |
Oct. 20th |
Schizophrenia (cont.) |
Krafnick |
Oct. 25th |
ADHD |
Ullrich |
Oct. 27th |
ADHD (cont.), Paper Presentation |
Ullrich |
Nov. 1st |
Midterm Examination | |
Nov. 3rd |
Development | Dumanis |
Nov. 8th |
Mental Retardation | Martin |
Nov. 10th |
Reproductive Behavior | Connor |
Nov. 15th |
Social Behavior |
Smirnov |
Nov. 17th |
Social Behavior (cont.), Psychopathy |
Smirnov, Ihne |
Nov. 22nd |
Autism, Paper Presentation |
Lozier |
Nov. 29th |
Autism, Circadian Rhythm |
Lozier, Randall |
Dec. 1st |
Sleep and Arousal |
Wolff |
Dec. 6th |
Brainstem Control of Life, Paper Presentation |
Niedringhaus |
TBD | Final Exam |