FUNDAMENTALS OF HUMAN PHYSIOLOGY

PBIO501     St. Mary's 107

 

 COURSE DIRECTOR:

Dr. Jagmeet Kanwal                Room WP09A Research Bldg.                                    687-1305

kanwalj@georgetown.edu

COURSE CO-DIRECTOR:

Dr. Joanna B. Kitlinska           Room 235A Basic Science                                                687-5229

Jbk4@georgetown.edu

FACULTY:

Dr. Aviad Haramati                Room 213 Basic Science                                               687-1021

                                                   haramati@georgetown.edu

Dr. Michael D. Lumpkin        Room 247 Basic Science                                               687-1517

mlumpk01@georgetown.edu

Dr. Susan E. Mulroney           Room 253 Basic Science                                               687-1017

mulrones@georgetown.edu

Dr. Aruna Natarajan               Room 5414 CCC Medical Ctr                                      444-2468

an5@georgetown.edu

Dr. Adam K. Myers                Room 207 Basic Science                                               687-1766

myersa@georgetown.edu

Dr. Stefano Vicini                    Room  225 Basic Science                                              687-1567

svcin01@georgetown.edu

Dr. Jian-Young Wu                 Room WP24A Research Bldg.                                    687-1614

wuj@georgetown.edu

 

 

COURSE OBJECTIVE

 

The goal of the Fundamentals of Human Physiology  course is to provide the student with a basic understanding of the physiological basis of medicine.  The essential concepts of physiology and mechanisms of body function are presented at various levels of organization ranging from the cellular and molecular, to the tissue and organ system level.  Emphasis is also placed on understanding the integrated regulation of various body processes among several systems.

 

FORMAT OF THE COURSE

 

The material in this course is presented by way of a variety of settings: lectures, problem-solving workshops, and small group tutorials.  As described below, each is designed to serve a different educational goal and together they provide an appropriately stimulating atmosphere for learning.  Virtually every major lecture series is presented by a faculty member who is actively working (and is a recognized expert) in that field of research.  At the beginning of the course each student will receive a handout containing the schedule and the educational objectives for each lecture series, sample problems, and additional relevant material.  The objectives represent the required knowledge and skills, and are realistically achievable if students spend time studying and solving problems, and participate in the tutorials and discussion sessions.

 

Lectures:  Didactic lectures are an efficient way of presenting material to a large class.  However, in an effort to move away from passive student learning, less than half of the contact hours in this course will be in lectures.  Thus, lectures will not cover all the required material, but will focus on specific concepts.

 

Problem-Solving Workshops:  These sessions will be given in the large lecture hall, but will not be didactic lectures.  Rather, the aim of these teaching sessions is to improve students' problem-solving skills by working through several quantitative problems related to the particular physiological system under study.

 

Small Group Tutorials:  These are two-hour sessions during which several clinical or pathophysiological cases are discussed to illustrate the application of basic physiological principles and concepts.

 

Review Sessions:  Periodic review sessions are scheduled throughout the course.  The format will be question and answer (not another lecture) and attendance is optional.

 

 

EXAMINATIONS

 

Two examinations will be given:  a mid-term and a final.  The tests will utilize National Board-type questions, which will be prepared by the individual lecturers and will be based entirely on the specific objectives for each lecture series and/or problem-solving workshop.  However, because the lecture series will not cover all the required material, students who depend entirely on course lecture notes will be handicapped.

 

 

GRADES

 

The course grade will be determined from the results of the two examinations, each weighted according to the number of questions.

 

 

FACULTY AVAILABILITY

 

Department policy encourages faculty to be available to all students who wish to discuss relevant material.  Each lecturer is generally available in his/her office during the late afternoon for such discussions.  Students not achieving an appropriate level of competence are strongly urged to contact the Course Director for advice.  Help should be sought promptly since the course moves on relentlessly.  The faculty members teaching this course will have office hours for meeting with students during the period of their lectures and before examinations.  General problems should be discussed with class officers or class Curriculum Committee representatives.  These representatives will meet periodically with the Course Director.

 

 

ATTENDANCE

 

School policy requires attendance at all teaching sessions.  In particular, small group sessions such as small group tutorials and problem-based learning sessions are important parts of the learning experience in physiology.  Therefore, attendance and participation in these exercises are mandatory.

GENERAL TEXTBOOKS IN PHYSIOLOGY

 

One of the following general textbooks is required.

            Principles of Physiology, Berne and Levy (3rd Edition, Mosby, 2000)

            This new textbook is concise and easy to read.  Each section contains excellent color figures and numerous clinical correlations that are very helpful.

OR

            Textbook of Medical Physiology, Guyton and Hall (10th Edition, Saunders, 2000)

            This classical textbook is favored by many students for its readability.  It has been updated and offers a comprehensive treatment of human physiology.  It is also the perferred textbook for the cardiovascular section.

 

Fundamentals of Human Physiology Course Schedule - 2008
Note that these dates are shifted by 2, but the order is correct

Week  1 

Date

1/07

1/08

1/09

1/10

1/11

Day

Monday

Tuesday

Wednesday

Thursday

Friday


1:15
to
2:05

 



 

 


Body Fluid Compartments

 

AH

 


Cell Membrane Properties

 

JYW


2:15
to
3:05

 


 

 


Osmosis

 

 

AH

 


PSW:

Body Fluid Shifts

 

AH

  

Week  2 

Date

1/14

1/15

1/16

1/17

1/18

Day

Monday

Tuesday

Wednesday

Thursday

Friday


1:15
to
2:05

 


Introduction to the Nervous System

 

JYW

 



 

Axonal Function

 

JYW

 


Synapse

 

 

 

JK


2:15
to
3:05

 

 

PSW:  Nernst Equation

 

JYW

 

 

PSW:  Action Potential

 

JYW

 

Sensory and Motor Systems

 

JK

 

Week  3

Date

1/21

1/22

1/23

1/24

1/25

Day

Monday

Tuesday

Wednesday

Thursday

Friday


1:15
to
2:05

 

 

 

Holiday

ACTUALLY

    1/19

 


Muscle Physiology: Skeletal

 

JK

 

Autonomic Function and Reflex Pathways

 

JK


2:15
to
3:05

 

 

 

 

Muscle Physiology: Smooth and Cardiac

 

JK

 

                  

 

  

Week  4 

Date

1/28

1/29

1/30

1/31

2/1

Day

Monday

Tuesday

Wednesday

Thursday

Friday


1:15
to
2:05

 

 

Hypothalamic-Pituitary Relationships I

 

MDL

 

 

Endocrinology of Growth

 

 

MDL

 

 

Endocrinology of Pregnancy, Labor, & Lactation

 

MDL


2:15
to
3:05

 

Hypothalamic-Pituitary Relationships II

 

 

MDL

 

 

Endocrinology of the Ovary & Female Reproductive Tract

 

MDL

 

Endocrinology of the Testis & Male Reproductive Tract

 

 

MDL

 

Week  5 

Date

2/4

2/5

2/6

2/7

2/8

Day

Monday

Tuesday

Wednesday

Thursday

Friday


1:15
to
2:05

 

 

Endocrinology of

the Thyroid Gland

 

 

MDL

 

 

Endocrinology of the Adrenal Cortex

 

MDL

 


Endocrine

Physiology of Stress

 

MDL


2:15
to
3:05

 

 

Endocrinology of the Pancreas

 

 

MDL

 

 

Endocrinology of Calcium Regulation

 

MDL

 


Endocrine

Case-Based

Tutorials

 

MDL

  

Week  6 

Date

2/11

2/12

2/13

2/14

2/15

Day

Monday

Tuesday

Wednesday

Thursday

Friday


1:15
to
2:05

 

 

Review

 

 

 

 

 

AH, JYW, JK, MDL

 


Exam I

 


 Cardiovascular Physiology:  Overview of Circulation and Pressure

 

 

AKM


2:15
to
3:05

 

 

   Review

 

 

 

AH, JYW, JK, MDL

 

Exam I

 


Cardiac Electro-physiology

 

 

SV


Week  7 

Date

2/18

2/19

2/20

2/21

2/22

Day

Monday

Tuesday

Wednesday

Thursday

Friday


1:15
to
2:05

 

HOLIDAY

 

ACTUALLY

   2/16

 

 

The Electro-cardiogram

 

SV

 

Cardiac Cycle

 

 

 

AKM


2:15
to
3:05

 

 

 

 

Introduction to Arrhythmias

 

SV

 

 

Regulation of Cardiac Output

 

AKM

 

Week  8 

Date

2/25

2/26

2/27

2/28

2/29

Day

Monday

Tuesday

Wednesday

Thursday

Friday


1:15
to
2:05

 

Cardiac Performance and Assessment I

 

AKM

 


 Biophysics of Circulation

 

 

 

AKM

 

 

Local Control of Circulation

 

 

 

AKM


2:15
to
3:05

 

 

Cardiac Performance and Assessment II

 

AKM

 

 Micro-circulation

 

 

 

 

AKM

 

Neurohumoral Regulation of Arterial Pressure

 

 

AKM


Week  9    NOTE THAT SPRING BREAK IS MARCH 9-13, 2008

Date

3/3

3/4

3/5

3/6

3/7

Day

Monday

Tuesday

Wednesday

Thursday

Friday


1:15
to
2:05

 

 

 

         S

 

 

  P               R

 

 

          I

 

 

         N

 

 

          G


2:15
to
3:05

 

 

 

       B

 

 

        R

 

 

       E

 

 

          A

 

 

        K

  

Week  10 

Date

3/10

3/11

3/12

3/13

3/14

Day

Monday

Tuesday

Wednesday

Thursday

Friday


1:15
to
2:05

 

 

PSW: Integrated Assessment of CV Function

 

 

AKM

 

Exercise Physiology

 

 

 

 

 

AKM

 

 

Introduction to Respiratory Physiology:  Structure and Function

 

AN


2:15
to
3:05

 

 

Special Circulations

 

AKM

 

 

Hemostasis

 

 

AKM

 

 

Mechanics of Respiration

 

AN

 

Week  11 

Date

3/17

3/18

3/19

3/20

3/21

Day

Monday

Tuesday

Wednesday

Thursday

Friday


1:15
to
2:05

 

 

Ventilation and Gas Exchange

 

 

AN

 

 

Transport of Oxygen

and Carbon Dioxide

 

AN

 

Good Friday

 


2:15
to
3:00

 

 

Ventilation-Perfusion Relationships

 

AN

 

 

Acid-Base

Balance

 

 

AN

 

 

  

Week  12 

Date

3/24

3/25

3/26

3/27

3/28

Day

Monday

Tuesday

Wednesday

Thursday

Friday


1:15
to
2:05

 

Easter Monday

 

 

 

Control of Ventilation

 

AN

 

Review

 

 

 

AKM, SV, AN


2:15
to
3:05

 

 

 

 

PSW: Assessing Pulmonary Function

 

AN

 

Review

 

 

 

 

 

AKM, SV, AN


Week  13 

Date

3/31

4/1

4/2

4/3

4/4

Day

Monday

Tuesday

Wednesday

Thursday

Friday


1:15
to
2:05

 

 

Exam II

 

 

Kidney Structure and Function

 

AH    

 

PSW:  Assessing Renal Function

 

AH


2:15
to
3:05

 

Exam II

 

 

 

Glomerular Filtration  

 

AH 

 

Tubular Transport

Processes

 

AH

  

Week  14 

Date

4/7

4/8

4/9

4/10

4/11

Day

Monday

Tuesday

Wednesday

Thursday

Friday


1:15
to
2:05

 

Study day

 


Urine Concentration/

Dilution

 

AH

 

Regulation of Sodium Reabsorption 
      

AH


2:15
to
3:05

 

 

 

Renal Hemo-dynamics



 

 

AH

 

Regulation of ECF Volume

 

 

 

AH


Week  15 

Date

4/14

4/15

4/16

4/17

4/18

Day

Monday

Tuesday

Wednesday

Thursday

Friday


1:15
to
2:05

 

 

Regulation of ECF Osmolarity

 

AH

 

 

Renal Regulation of Acid-Base Balance

 

AH

 

 

Overview

of the GI

System

 

 

SEM


2:15
to
3:05

 

PSW: Assesment of Tubular Tranport

 

AH

 

 

 

Clinical Acid-Base Disorders

 

 

AH

 

GI Motility

 

 

 

SEM

  

Week  16 

Date

4/21

4/22

4/23

4/24

4/25

Day

Monday

Tuesday

Wednesday

Thursday

Friday


1:15
to
2:05

 

 

Secretions of the Mouth, Esophagus, and Stomach

 

SEM

 

 

Hepatobiliary

Function

 

 

 

SEM

 

 

Digestion and Absorption

 

  

 

SEM


2:15
to
3:05

 

 

Secretions of the liver, Pancreas, and Intestine

 

SEM

 

 

 

Digestion and Absorption

 

 

 

 

SEM


Week  17 

Date

4/28

4/29

4/30

5/1

5/2

Day

Monday

Tuesday

Wednesday

Thursday

Friday


1:15
to
2:05

 

 

G.I.

Case-Based Tutorials

   

SEM

 

 

 

Reviews

 

 

 

 

AH, SEM

 

 

 

 

Exams

Start

(Exam III to be scheduled)


2:15
to
3:05

 

 G.I.

Case-Based Tutorials

   

SEM

 

 

 

Reviews

 

 

 

AH, SEM

 

 

 

 

 

 

 Week  18

Date

5/5

5/6

5/7

5/8

5/9

Day

Monday

Tuesday

Wednesday

Thursday

Friday


1:15
to
2:05

 

 

EXAM

WEEK

(Exam III to be scheduled)

 

 

 

 

 

 

 

 


2:15
to
3:05