FUNDAMENTALS OF HUMAN PHYSIOLOGY
PBIO501 St. Mary's 107
COURSE DIRECTOR:
Dr. Jagmeet Kanwal Room WP09A Research Bldg. 687-1305
kanwalj@georgetown.edu
COURSE CO-DIRECTOR:
Dr. Joanna B. Kitlinska Room 235A Basic Science 687-5229
Jbk4@georgetown.edu
FACULTY:
Dr. Aviad Haramati Room 213 Basic Science 687-1021
haramati@georgetown.edu
Dr. Michael D. Lumpkin Room 247 Basic Science 687-1517
mlumpk01@georgetown.edu
Dr. Susan E. Mulroney Room 253 Basic Science 687-1017
mulrones@georgetown.edu
Dr. Aruna Natarajan Room 5414 CCC Medical Ctr 444-2468
an5@georgetown.edu
Dr. Adam K. Myers Room 207 Basic Science 687-1766
myersa@georgetown.edu
Dr. Stefano Vicini Room 225 Basic Science 687-1567
svcin01@georgetown.edu
Dr. Jian-Young Wu Room WP24A Research Bldg. 687-1614
wuj@georgetown.edu
COURSE OBJECTIVE
The goal of the Fundamentals of Human Physiology course is to provide the student with a basic understanding of the physiological basis of medicine. The essential concepts of physiology and mechanisms of body function are presented at various levels of organization ranging from the cellular and molecular, to the tissue and organ system level. Emphasis is also placed on understanding the integrated regulation of various body processes among several systems.
FORMAT OF THE COURSE
The material in this course is presented by way of a variety of settings: lectures, problem-solving workshops, and small group tutorials. As described below, each is designed to serve a different educational goal and together they provide an appropriately stimulating atmosphere for learning. Virtually every major lecture series is presented by a faculty member who is actively working (and is a recognized expert) in that field of research. At the beginning of the course each student will receive a handout containing the schedule and the educational objectives for each lecture series, sample problems, and additional relevant material. The objectives represent the required knowledge and skills, and are realistically achievable if students spend time studying and solving problems, and participate in the tutorials and discussion sessions.
Lectures: Didactic lectures are an efficient way of presenting material to a large class. However, in an effort to move away from passive student learning, less than half of the contact hours in this course will be in lectures. Thus, lectures will not cover all the required material, but will focus on specific concepts.
Problem-Solving Workshops: These sessions will be given in the large lecture hall, but will not be didactic lectures. Rather, the aim of these teaching sessions is to improve students' problem-solving skills by working through several quantitative problems related to the particular physiological system under study.
Small Group Tutorials: These are two-hour sessions during which several clinical or pathophysiological cases are discussed to illustrate the application of basic physiological principles and concepts.
Review Sessions: Periodic review sessions are scheduled throughout the course. The format will be question and answer (not another lecture) and attendance is optional.
EXAMINATIONS
Two examinations will be given: a mid-term and a final. The tests will utilize National Board-type questions, which will be prepared by the individual lecturers and will be based entirely on the specific objectives for each lecture series and/or problem-solving workshop. However, because the lecture series will not cover all the required material, students who depend entirely on course lecture notes will be handicapped.
GRADES
The course grade will be determined from the results of the two examinations, each weighted according to the number of questions.
FACULTY AVAILABILITY
Department policy encourages faculty to be available to all students who wish to discuss relevant material. Each lecturer is generally available in his/her office during the late afternoon for such discussions. Students not achieving an appropriate level of competence are strongly urged to contact the Course Director for advice. Help should be sought promptly since the course moves on relentlessly. The faculty members teaching this course will have office hours for meeting with students during the period of their lectures and before examinations. General problems should be discussed with class officers or class Curriculum Committee representatives. These representatives will meet periodically with the Course Director.
ATTENDANCE
School policy requires attendance at all teaching sessions. In particular, small group sessions such as small group tutorials and problem-based learning sessions are important parts of the learning experience in physiology. Therefore, attendance and participation in these exercises are mandatory.
GENERAL TEXTBOOKS IN PHYSIOLOGY
One of the following general textbooks is required.
Principles of Physiology, Berne and Levy (3rd Edition, Mosby, 2000)
This new textbook is concise and easy to read. Each section contains excellent color figures and numerous clinical correlations that are very helpful.
OR
Textbook of Medical Physiology, Guyton and Hall (10th Edition, Saunders, 2000)
This classical textbook is favored by many students for its readability. It has been updated and offers a comprehensive treatment of human physiology. It is also the perferred textbook for the cardiovascular section.
Fundamentals of Human
Physiology Course Schedule - 2008
Note that these dates are shifted by 2, but the order is
correct
Week 1
|
Date |
1/07 |
1/08 |
1/09 |
1/10 |
1/11 |
|
Day |
Monday |
Tuesday |
Wednesday |
Thursday |
Friday |
|
|
|
|
AH |
|
JYW |
|
|
|
|
AH |
|
Body Fluid Shifts
AH |
Week 2
|
Date |
1/14 |
1/15 |
1/16 |
1/17 |
1/18 |
|
Day |
Monday |
Tuesday |
Wednesday |
Thursday |
Friday |
|
|
JYW |
|
Axonal Function
JYW |
|
JK |
|
|
PSW: Nernst Equation
JYW |
|
PSW: Action Potential
JYW |
|
Sensory and Motor Systems
JK |
Week 3
|
Date |
1/21 |
1/22 |
1/23 |
1/24 |
1/25 |
|
Day |
Monday |
Tuesday |
Wednesday |
Thursday |
Friday |
|
|
Holiday ACTUALLY 1/19 |
|
JK |
|
Autonomic Function and Reflex Pathways
JK |
|
|
|
|
Muscle Physiology: Smooth and Cardiac
JK |
|
|
Week 4
|
Date |
1/28 |
1/29 |
1/30 |
1/31 |
2/1 |
|
Day |
Monday |
Tuesday |
Wednesday |
Thursday |
Friday |
|
|
Hypothalamic-Pituitary Relationships I
MDL |
|
Endocrinology of Growth
MDL |
|
Endocrinology of Pregnancy, Labor, & Lactation
MDL |
|
|
Hypothalamic-Pituitary Relationships II
MDL |
|
Endocrinology of the Ovary & Female Reproductive Tract
MDL |
|
Endocrinology of the Testis & Male Reproductive Tract
MDL |
Week 5
|
Date |
2/4 |
2/5 |
2/6 |
2/7 |
2/8 |
|
Day |
Monday |
Tuesday |
Wednesday |
Thursday |
Friday |
|
|
Endocrinology of the Thyroid Gland
MDL |
|
Endocrinology of the Adrenal Cortex
MDL |
|
Physiology of Stress
MDL |
|
|
Endocrinology of the Pancreas
MDL |
|
Endocrinology of Calcium Regulation
MDL |
|
Case-Based Tutorials
MDL |
Week 6
|
Date |
2/11 |
2/12 |
2/13 |
2/14 |
2/15 |
|
Day |
Monday |
Tuesday |
Wednesday |
Thursday |
Friday |
|
|
Review
AH, JYW, JK, MDL |
|
|
|
AKM |
|
|
Review
AH, JYW, JK, MDL |
|
Exam I |
|
SV |
|
Date |
2/18 |
2/19 |
2/20 |
2/21 |
2/22 |
|
Day |
Monday |
Tuesday |
Wednesday |
Thursday |
Friday |
|
|
HOLIDAY
ACTUALLY 2/16 |
|
The Electro-cardiogram
SV |
|
Cardiac Cycle
AKM |
|
|
|
|
Introduction to Arrhythmias
SV |
|
Regulation of Cardiac Output
AKM |
Week 8
|
Date |
2/25 |
2/26 |
2/27 |
2/28 |
2/29 |
|
Day |
Monday |
Tuesday |
Wednesday |
Thursday |
Friday |
|
|
Cardiac Performance and Assessment I
AKM |
|
AKM |
|
Local Control of Circulation
AKM |
|
|
Cardiac Performance and Assessment II
AKM |
|
Micro-circulation
AKM |
|
Neurohumoral Regulation of Arterial Pressure
AKM |
|
Date |
3/3 |
3/4 |
3/5 |
3/6 |
3/7 |
|
Day |
Monday |
Tuesday |
Wednesday |
Thursday |
Friday |
|
|
S |
P R |
I |
N |
G |
|
|
B |
R |
E |
A |
K |
Week 10
|
Date |
3/10 |
3/11 |
3/12 |
3/13 |
3/14 |
|
Day |
Monday |
Tuesday |
Wednesday |
Thursday |
Friday |
|
|
PSW: Integrated Assessment of CV Function
AKM |
|
Exercise Physiology
AKM |
|
Introduction to Respiratory Physiology: Structure and Function
AN |
|
|
Special Circulations
AKM |
|
Hemostasis
AKM |
|
Mechanics of Respiration
AN |
Week 11
|
Date |
3/17 |
3/18 |
3/19 |
3/20 |
3/21 |
|
Day |
Monday |
Tuesday |
Wednesday |
Thursday |
Friday |
|
|
Ventilation and Gas Exchange
AN |
|
Transport of Oxygen and Carbon Dioxide
AN |
|
Good Friday
|
|
|
Ventilation-Perfusion Relationships
AN |
|
Acid-Base Balance
AN |
|
|
Week 12
|
Date |
3/24 |
3/25 |
3/26 |
3/27 |
3/28 |
|
Day |
Monday |
Tuesday |
Wednesday |
Thursday |
Friday |
|
|
Easter Monday
|
|
Control of Ventilation
AN |
|
Review
AKM, SV, AN |
|
|
|
|
PSW: Assessing Pulmonary Function
AN |
|
Review
AKM, SV, AN |
|
Date |
3/31 |
4/1 |
4/2 |
4/3 |
4/4 |
|
Day |
Monday |
Tuesday |
Wednesday |
Thursday |
Friday |
|
|
Exam II |
|
Kidney Structure and Function
AH |
|
PSW: Assessing Renal Function
AH |
|
|
Exam II
|
|
Glomerular Filtration
AH |
|
Tubular Transport Processes
AH |
Week 14
|
Date |
4/7 |
4/8 |
4/9 |
4/10 |
4/11 |
|
Day |
Monday |
Tuesday |
Wednesday |
Thursday |
Friday |
|
|
Study day |
|
Dilution
AH |
|
Regulation of
Sodium Reabsorption AH |
|
|
|
|
Renal Hemo-dynamics
AH |
|
Regulation of ECF
Volume
AH |
|
Date |
4/14 |
4/15 |
4/16 |
4/17 |
4/18 |
|
Day |
Monday |
Tuesday |
Wednesday |
Thursday |
Friday |
|
|
Regulation of ECF Osmolarity
AH |
|
Renal Regulation of Acid-Base Balance
AH |
|
Overview of the GI System
SEM |
|
|
PSW: Assesment of Tubular Tranport
AH
|
|
Clinical Acid-Base Disorders
AH |
|
GI Motility
SEM |
Week 16
|
Date |
4/21 |
4/22 |
4/23 |
4/24 |
4/25 |
|
Day |
Monday |
Tuesday |
Wednesday |
Thursday |
Friday |
|
|
Secretions of the Mouth, Esophagus, and Stomach
SEM |
|
Hepatobiliary Function
SEM |
|
Digestion and Absorption
SEM |
|
|
Secretions of the liver, Pancreas, and Intestine
SEM |
|
|
|
Digestion and Absorption
SEM |
|
Date |
4/28 |
4/29 |
4/30 |
5/1 |
5/2 |
|
Day |
Monday |
Tuesday |
Wednesday |
Thursday |
Friday |
|
|
G.I. Case-Based Tutorials
SEM |
|
Reviews
AH, SEM |
|
Exams Start (Exam III to be scheduled) |
|
|
G.I. Case-Based Tutorials
SEM |
|
Reviews
AH, SEM |
|
|
Week 18
|
Date |
5/5 |
5/6 |
5/7 |
5/8 |
5/9 |
|
Day |
Monday |
Tuesday |
Wednesday |
Thursday |
Friday |
|
|
EXAM WEEK (Exam III to be scheduled) |
|
|
|
|
|
|
|
|
|
|
|